… Thus, we conclude that p120 has an essential role in barrier function and epithelial … role
for p120 in maintaining barrier function. However, the data also reveal a striking role for p120 in …

… Our results show that p120 does not regulate barrier function solely by regulating VE-Cad …
-VE-Cad mutant cannot restore barrier function in cells depleted of either p120 (Figure 2B) or …

… To determine whether binding of p120 is required for VE-cadherin to maintain barrier function,
we generated a fragment corresponding to the JMD, amino acids 600–697 of bovine VE-…

… The mechanisms by which catenins regulate cadherin function are not fully understood,
and the precise function of p120 catenin (p120ctn) has remained particularly elusive. In …

… have demonstrated a requirement for both p120 and β-catenin to maintain vascular barrier
function, and the conditional endothelial knockout of either catenin results in hemorrhages, …

… However, our data show that downregulation of p120 in the … -catenin expression were
reduced. These results are consistent with studies in which barrier function was not altered in p120-…

… of p120 impaired permeability barrier function To examine the role of p120 in permeability
barrier function, … the rate of barrier recovery following tape stripping to disrupt the barrier. Two …

… a role for this protein in vivo. Using conditional targeting in mice, we show that p120 null …
AJ components but no overt disruption in barrier function or intercellular adhesion. As the …

… to obvious breakdown of the epithelial barrier function and exposure to bacteria and other
gut … not obviously compromised, and the barrier function appeared intact. Here, inflammation …

… at the plasma membrane by p120-catenin (p120, also known as … In this setting, p120
translocates to the cytosol where it exerts … through conditional knockout of p120 in mice was …