p120-catenin is essential for maintenance of barrier function and intestinal homeostasis in mice

WG Smalley-Freed, A Efimov… - The Journal of …, 2010 - Am Soc Clin Investig
… Its function is regulated in part by p120-catenin (referred to herein as p120), a cytoplasmic
… effect of p120 deficiency in mouse small intestine and colon. p120 conditional KO mice were …

p120-Catenin is an obligate haploinsufficient tumor suppressor in intestinal neoplasia

SP Short, J Kondo, WG Smalley-Freed… - The Journal of …, 2017 - Am Soc Clin Investig
… Here, using conditional p120 knockout in Apc-sensitized mouse models of intestinalp120
loss in the intestine, we previously developed a TAM regime in p120 fl/fl ; Villin CreERT2 mice

Adenoma formation following limited ablation of p120-catenin in the mouse intestine

WG Smalley-Freed, A Efimov, SP Short, P Jia, Z Zhao… - PloS one, 2011 - journals.plos.org
… Previously, we reported that p120 is essential in the intestine for … our p120 conditional
knockout mouse, we evaluated the effects of targeted p120 ablation in the small intestine and colon

p120-catenin regulates WNT signaling and EMT in the mouse embryo

R Hernández-Martínez, N Ramkumar… - Proceedings of the …, 2019 - National Acad Sciences
p120-catenin may play an important role in EMTs. Here, we describe the role of p120-catenin
in mouse … in some tumors: For example, mosaic deletion of p120 in the intestine leads to …

p120-catenin in cancer–mechanisms, models and opportunities for intervention

RCJ Schackmann, M Tenhagen… - Journal of cell …, 2013 - journals.biologists.com
… knockout of p120 in mice was recently linked to tumor formation, indicating that p120 can
also … Intriguingly, when reverting to mosaic p120 deletion in the mouse small intestine, the …

[HTML][HTML] p120-catenin: Past and present

AB Reynolds - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 2007 - Elsevier
… Of particular interest are in vivo transgenic studies in the intestine … Studies using direct
p120-ablation in mice are underway to … of targeted p120 ablation in mice will reveal whether p120-…

[HTML][HTML] p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas

AM Hendley, E Provost, JM Bailey, YJ Wang… - Developmental …, 2015 - Elsevier
… the biology of p120 catenin in pancreas development, we ablated p120 catenin in mouse
pancreatic progenitor cells, which resulted in deletion of p120 catenin in all epithelial lineages …

The homeodomain transcription factors Cdx1 and Cdx2 induce E-cadherin adhesion activity by reducing β-and p120-catenin tyrosine phosphorylation

T Ezaki, RJ Guo, H Li, AB Reynolds… - … -Gastrointestinal and …, 2007 - journals.physiology.org
… robust p120-catenin/E-cadherin interactions. We specifically investigated β- and p120-catenin
for … We restored β- and p120-catenin tyrosine phosphorylation in Cdx2-expressing cells by …

p120-Catenin is required for mouse vascular development

RG Oas, K Xiao, S Summers, KB Wittich… - Circulation …, 2010 - Am Heart Assoc
… of p120 in mammalian vascular development by generating a conditionally mutant mouse
lacking endothelial p120 … deletion strategy was used to ablate p120 expression, using the Tie2 …

p120 catenin suppresses basal epithelial cell extrusion in invasive pancreatic neoplasia

AM Hendley, YJ Wang, K Polireddy, J Alsina, I Ahmed… - Cancer research, 2016 - AACR
… Pdx1 ; p120 f/f mice, we reported that p120 catenin is required … To determine the function of
p120 catenin in adult mouse … transgenic mice harboring floxed alleles of p120 catenin (p120