… The first cDNAs encoding P2X receptor subunits were isolated … P2X receptors were ion
channels gated by ATP. This review deals first with the molecular properties of the P2X receptors …

… Whereas a number of P2X receptors mediate fast synaptic responses to the transmitter ATP,
… P2X receptors in the CNS appear to belong mostly to the P2X 2 , P2X 4 or P2X 4 /P2X 6 …

… of recent work on the molecular basis of the properties of P2X receptors. In particular, to … of
P2X receptor subunits, channel regulation and desensitisation, targeting, the molecular basis …

… any conclusive demonstration of the physiological function of ATP-operated P2X receptors.
… been suspected [50–52] and is now beginning to be worked out in molecular detail [53–55]. …

… tool for studying ionotropic receptors. Recently, modeling studies carried out on P2X receptors
have advanced our knowledge of the P2X receptor structure-function relationships. This …

… of the molecular structure of P2X receptors and its relationship to their function. And yet,
despite the numerous important discoveries made over the years, there are many aspects of …

… that four of the seven P2X receptor subtypes are found in the sympathetic ganglion cells
used in this study [85] and therefore, the identity of the P2X receptor responsible for the ATP-…

… of the physiological and pathophysiological roles of P2X receptors have expanded
immeasurably. It was a surprise that the genes encoding seven different P2X subunits were cloned, …

… the physiological roles that P2X receptors play in such organisms. Such information is likely
to elucidate the biological benefits that have led to the retention of P2X receptors in humans …

… our understanding of their molecular and physiological function and their validation as drug
… of P2X receptors and gives an update on recent developments in the search for P2X subtype-…