[HTML][HTML] Function of the P2X7 receptor in hematopoiesis and leukemogenesis
X He, Y Zhang, Y Xu, L Xie, Z Yu, J Zheng - Experimental Hematology, 2021 - Elsevier
… and leukemogenesis. Here, we summarize the biological functions of P2X7 receptor during
both normal hematopoiesis and leukemogenesis. In particular, we found that ATP levels are …
both normal hematopoiesis and leukemogenesis. In particular, we found that ATP levels are …
Expression of P2X7 in human hematopoietic cell lines and leukemia patients
XJ Zhang, GG Zheng, XT Ma, YH Yang, G Li, Q Rao… - Leukemia research, 2004 - Elsevier
… Stimulation of the P2X7 receptor by ATP caused post-translational processing of precursors
of IL-1β and IL-18 in human monocytes [7], [8], stimulation of JNK activity and induction of …
of IL-1β and IL-18 in human monocytes [7], [8], stimulation of JNK activity and induction of …
Involvement of P2 receptors in hematopoiesis and hematopoietic disorders, and as pharmacological targets
KJ Filippin, KFS de Souza, RT de Araujo Júnior… - Purinergic …, 2020 - Springer
… The participation of the P2X7 receptor in hematopoiesis has also been demonstrated. The
… leukemia-AML) lineages. In HL-60 and J6-1 (myeloid leukemia) lineages, the P2X7 receptor …
… leukemia-AML) lineages. In HL-60 and J6-1 (myeloid leukemia) lineages, the P2X7 receptor …
[HTML][HTML] Extracellular ATP induces apoptosis through P2X7R activation in acute myeloid leukemia cells but not in normal hematopoietic stem cells
V Salvestrini, S Orecchioni, G Talarico, F Reggiani… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… Acute myeloid leukemia (AML) is a hematopoietic stem cell … Approximately 50% of leukemia
patients survive their disease… the major limiting factors in leukemia treatment. Despite the …
patients survive their disease… the major limiting factors in leukemia treatment. Despite the …
[HTML][HTML] Expression and function of P2 receptors in hematopoietic stem and progenitor cells
W Feng, L Wang, G Zheng - Stem Cell Investigation, 2015 - ncbi.nlm.nih.gov
… The activation of P2X receptors resulted influx of extracellular … of P2X7 receptor was
described. For instance, an N187D point mutation was detected in P2X7 receptor from a leukemia …
described. For instance, an N187D point mutation was detected in P2X7 receptor from a leukemia …
High level P2X7-mediated signaling impairs function of hematopoietic stem/progenitor cells
… leukemogenesis have not been established. In this study, the expression of P2X7 in
hematopoietic … Significance of P2X7 receptor variants to human health and disease. Recent …
hematopoietic … Significance of P2X7 receptor variants to human health and disease. Recent …
[HTML][HTML] Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models
X He, J Wan, X Yang, X Zhang… - The Journal of …, 2021 - Am Soc Clin Investig
… decided to examine the function of P2X7 during leukemogenesis. We first examined the
mRNA levels of P2x7 in both normal hematopoietic cells and leukemia cells. Interestingly, the …
mRNA levels of P2x7 in both normal hematopoietic cells and leukemia cells. Interestingly, the …
[HTML][HTML] P2X7 Receptor Activation By ATP As Target of Novel Therapies in Acute Myeloid Leukemia
V Salvestrini, S Orecchioni, F Reggiani, G Talarico… - Blood, 2015 - Elsevier
… We previously demonstrated that ATP is a potent stimulator of normal hematopoietic stem
cell compartment while inhibiting acute myeloid leukemia (AML) cells. Based on this …
cell compartment while inhibiting acute myeloid leukemia (AML) cells. Based on this …
… P2X4 purinergic receptor has emerged as a potent regulator of hematopoietic stem/progenitor cell mobilization and homing—a novel view of P2X4 and P2X7 receptor …
… P2X4 receptors, which shows ~50% sequence similarity to P2X7 … receptor antagonist
PSB12054 as well as P2X4-KO mice, we found that the P2X4 receptor, similar to P2X7 receptor, …
PSB12054 as well as P2X4-KO mice, we found that the P2X4 receptor, similar to P2X7 receptor, …
p53-dependent induction of P2X7 on hematopoietic stem and progenitor cells regulates hematopoietic response to genotoxic stress
… P2X7 expression on HSCs and HSPCs in response to genotoxic stress. We further demonstrate
the role of P2X7 in hematopoietic … leukemia-initiating cells and to inhibit leukemogenesis …
the role of P2X7 in hematopoietic … leukemia-initiating cells and to inhibit leukemogenesis …
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