… P2X7R in chondrocytes promotes extracellular matrix degradation and IL-1β release via
NF-κB/NLRP3 … We also examined the effects of a P2X7R antagonist, agonist, and pathway …

… Purinergic 2X7 receptor is essential for activating the NLRP3 … the NLRP3 inflammasome
via the mechanism of P2X7R. First, P2X7R siRNA was administered to knock-down the P2X7R …

… P2X7 receptor is activated, it could promote or impair NLRP3 activation, although the role of
the P2X7 receptor in impairing NLRP3 … For this reason, P2X7 receptor-dependent secretome …

… For this reason, we explored the hypothesis that P2X7R and NLRP3 were localized in the …
that P2X7R modulates NLRP3 expression at the mRNA and protein level; P2X7R and NLRP3 …

… P2X7R and its effect on NLRP3 remains largely underdetermined. In this study, we aimed to
investigate the role of P2X7R in the activation of NLRP3 … of P2X7R and activation of NLRP3 …

… inflammation and activated by the P2X7R, including the NLRP3 inflammasome, NF-kB, NFAT…
of P2X7R in chronic diseases. The possible therapeutic applications of P2X7R antagonists …

… P2x7R reduced protein expression of NLRP3 and α-SMA, and suppressed deposition
and secretion of type I collagen. The involvement of P2X7R-mediated NLRP3 … the P2x7R-NLRP3 …

… P2X7R with BBG could effectively inhibit BCP due to suppressing the expression of NF-κB
p-p65, NLRP3 … , the nuclear translocation of NFκB, and the synthesis of NLRP3 and IL-1β in …

… NFκB inhibitor IκB-α was reduced by A839977 and in P2X7 knockout mice. In summary,
mechanical trauma to the retina primed NLRP3 … and autostimulation of the P2X7 receptor. As the …

… The nuclear factor-kappa B (NF- kB) and NLRP3 inflammasome activation by P2X7/NLRP3/caspase
1 … This review highlights the potentials of drugs acting on the P2X7 receptor and its …