… An additional mechanism that can regulate p38 MAPK activity is the phosphorylation on
Thr 123 [73], a residue located at the docking groove for substrates and regulators. This …

… Thus, we find that p38 activity is important during cleavage stages, as in mouse embryos,
and is required for axial specification, as in Drosophila embryos. Since there is only a single …

… is p38 mitogen-activated protein kinase (MAPK). As a result of modifying the activity of p38
in … activity in RMS cells markedly induced the activity of p38, while constitutive activation of …

… We examined the activity and expression of the p38 MAPK pathway members, … time, that
glomerular p38 MAPK activity is increased in early DN and that the activation of p38 MAPK is …

… damage by both directly upregulating p38 MAPK activity and downregulating a key p38
MAPK shut off mechanism by reducing ACE2 activity. Furthermore, p38 MAPK activation could …

… hearts were compared to non-failing hearts for both p38 MAPK protein level and total p38
MAPK activity. Western blotting techniques demonstrated no significant changes in total p38 …

… that interferes with p38 MAPK phosphorylation and/or its activity. In this report, we describe
the in vivo effect of a novel oral inhibitor of p38 MAPK phosphorylated activity, which results …

… Similarly, in this study we found that decreased p38 MAPK activity caused by compound
mutations of Mkk3 and Mkk6 causes growth arrest defects (Fig. 6) and increased tumorigenesis (…

… inhibit p38 MAPK activity that regulates IL-10 expression via Sp1. Treatment of 2F7 cells
with Rituximab or the p38 inhibitor SB203580 inhibited the constitutive p38 MAPK activity and …

… of p38 MAPK activity phosphorylation of p38 MAPK as well … p38 MAPK activity during ischaemia
in nonp38 MAPK by … a significant increase in kinase activity in preconditioned model,2,6,…