… discuss the mechanisms, circumstances and consequences of p38 activation in the heart.
The purpose is to evaluate p38 inhibition as a potential therapy for ischaemic heart disease. …

… evaluating different p38 MAPK inhibitor compounds in disease models such … in Cardiovascular
Disease In order to determine the effects of p38 MAPK inhibition in cardiovascular disease…

… Ischemic heart disease, the leading cause of death … produced by a coronary artery occlusion
that impairs cardiac blood flow… Moreover, p38 inhibition with an antioxidant during ischemia–…

… inhibiting p38 activity to treat cardiac hypertrophy, ischemic … effective p38 targeted therapies
for ischemic heart diseases. … Role of G proteins and modulation of p38 MAPK activation in …

… Ischaemic heart disease is a major cause of morbidity and mortality, … inhibitors of the
p38-MAPK pathway is ongoing and, despite the abundance of studies using p38-MAPK inhibitors in …

… The question is, which of the biological processes implicated in progressive adverse remodeling
and heart failure are influenced by p38 inhibition? The most thoroughly investigated are …

… In patients with end-stage heart failure and ischaemic heart disease, increased p38 … of
p38 MAPK inhibition in cardiovascular disease associated with inflammation and cardiac …

… of mortality in 2030 will still be ischemic heart disease. Currently, the most effective method
… cell death, and the inhibition of p38 MAPK activation in the ischemic heart has been shown to …

… p38-MAPK(s) and ERKs are expressed in the human heart and the activities of JNKs and
p38-MAPK(s) were increased in heart failure … cell NF- B and inhibits apoptosis in a p38 cardiac …

… In pre-clinical models of cardiovascular disease, p38 MAPK inhibition improves endothelial
… of future cardiovascular events (34,35). We suggest that the role of p38 MAPK inhibition …