Involvement of p38 MAPK in reactive astrogliosis induced by ischemic stroke
GR Choudhury, MG Ryou, E Poteet, Y Wen, R He… - Brain research, 2014 - Elsevier
… p38 inhibition and knockout of p38 MAPK. In addition, both knockout and inhibition of p38
MAPK also reduced astrocyte … has indicated that reactive astrocytes have potentially beneficial …
MAPK also reduced astrocyte … has indicated that reactive astrocytes have potentially beneficial …
[HTML][HTML] In vitro P38MAPK inhibition in aged astrocytes decreases reactive astrocytes, inflammation and increases nutritive capacity after oxygen-glucose deprivation
M Revuelta, A Elicegui, T Scheuer… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… signaling has been identified to be upregulated in neurons, astrocytes and microglia … inhibitor
(PH-797804), we show that p38MAPK pathway has an important role in aged astrocytes for …
(PH-797804), we show that p38MAPK pathway has an important role in aged astrocytes for …
p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes
… Studies of reactive astrocyte elimination suggest that … effects by reactive astrocytes in
inhibiting oligodendrocyte … using p38 MAPK inhibitors indicated that astrocytes upregulate …
inhibiting oligodendrocyte … using p38 MAPK inhibitors indicated that astrocytes upregulate …
Delayed induction of p38 MAPKs in reactive astrocytes in the brain of mice after KA-induced seizure
Y Che, YM Yu, PL Han, JK Lee - Molecular brain research, 2001 - Elsevier
… whether or not the two p38 MAPK isoforms, p38α and p38β, are … We demonstrated that the
delayed induction of p38 MAPK … by the NOS inhibitor, 7-NI, that inhibited the neuronal death …
delayed induction of p38 MAPK … by the NOS inhibitor, 7-NI, that inhibited the neuronal death …
ROS detoxification and proinflammatory cytokines are linked by p38 MAPK signaling in a model of mature astrocyte activation
A Nahirnyj, I Livne-Bar, X Guo, JM Sivak - PloS one, 2013 - journals.plos.org
… Here we describe a system for rapid culture of mature astrocytes … When primary astrocytes
were exposed to reactive oxygen … Additionally, multiplex cytokine profiling detected p38 MAPK-…
were exposed to reactive oxygen … Additionally, multiplex cytokine profiling detected p38 MAPK-…
Toll-like receptors control p38 and JNK MAPK signaling pathways in rat astrocytes differently, when cultured in normal or high glucose concentrations
DV Chistyakov, NV Azbukina, AA Astakhova… - Neurochemistry …, 2019 - Elsevier
… Moreover, the inhibitors of p38 MAPK or JNK did not influence the … inhibition with SP600126
completely abolished the LPS-mediated decrease of PPARγ, while the p38 MAPK inhibitor …
completely abolished the LPS-mediated decrease of PPARγ, while the p38 MAPK inhibitor …
Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β
F Correa, C Mallard, M Nilsson, M Sandberg - Neurobiology of disease, 2011 - Elsevier
… shown that inhibition of p38 MAPK signalling with SB203580 (20 μM) inhibited the
decrease in Nrf2 and γGCL-M protein levels and reduced H 2 O 2 induced death in astrocyte-rich …
decrease in Nrf2 and γGCL-M protein levels and reduced H 2 O 2 induced death in astrocyte-rich …
Delayed and differential induction of p38 MAPK isoforms in microglia and astrocytes in the brain after transient global ischemia
CS Piao, Y Che, PL Han, JK Lee - Molecular brain research, 2002 - Elsevier
… of SB203580, an inhibitor of p38 MAPK, reduced the … and expression of the two p38 MAPK
isoforms, p38α and p38β, … -immunoreactive cells resembled reactive astrocytes, in which the …
isoforms, p38α and p38β, … -immunoreactive cells resembled reactive astrocytes, in which the …
Gypenoside IX suppresses p38 MAPK/Akt/NFκB signaling pathway activation and inflammatory responses in astrocytes stimulated by proinflammatory mediators
X Wang, L Yang, L Yang, F Xing, H Yang, L Qin, Y Lan… - Inflammation, 2017 - Springer
… In present study, the anti-inflammatory effects of GP IX were investigated in reactive astrocytes
… p38 MAPK signaling pathways, suggesting that GP IX inhibited the activation of astrocytes …
… p38 MAPK signaling pathways, suggesting that GP IX inhibited the activation of astrocytes …
Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo
D Li, N Liu, HH Zhao, X Zhang, H Kawano, L Liu… - Journal of …, 2017 - Springer
… astrocyte activation induced by IL-1β stimulation in vitro and traumatic brain injury in vivo;
inhibition of ERK, JNK, or p38MAPK … cell hypertrophy to attenuate the astrocyte activation; Sirt1 …
inhibition of ERK, JNK, or p38MAPK … cell hypertrophy to attenuate the astrocyte activation; Sirt1 …