Involvement of p38 MAPK in reactive astrogliosis induced by ischemic stroke

GR Choudhury, MG Ryou, E Poteet, Y Wen, R He… - Brain research, 2014 - Elsevier
… p38 inhibition and knockout of p38 MAPK. In addition, both knockout and inhibition of p38
MAPK also reduced astrocyte … has indicated that reactive astrocytes have potentially beneficial …

[HTML][HTML] In vitro P38MAPK inhibition in aged astrocytes decreases reactive astrocytes, inflammation and increases nutritive capacity after oxygen-glucose deprivation

M Revuelta, A Elicegui, T Scheuer… - Aging (Albany …, 2021 - ncbi.nlm.nih.gov
… signaling has been identified to be upregulated in neurons, astrocytes and microglia … inhibitor
(PH-797804), we show that p38MAPK pathway has an important role in aged astrocytes for …

p38α (MAPK14) critically regulates the immunological response and the production of specific cytokines and chemokines in astrocytes

U Lo, V Selvaraj, JM Plane, OV Chechneva, K Otsu… - Scientific reports, 2014 - nature.com
… Studies of reactive astrocyte elimination suggest that … effects by reactive astrocytes in
inhibiting oligodendrocyte … using p38 MAPK inhibitors indicated that astrocytes upregulate …

Delayed induction of p38 MAPKs in reactive astrocytes in the brain of mice after KA-induced seizure

Y Che, YM Yu, PL Han, JK Lee - Molecular brain research, 2001 - Elsevier
… whether or not the two p38 MAPK isoforms, p38α and p38β, are … We demonstrated that the
delayed induction of p38 MAPK … by the NOS inhibitor, 7-NI, that inhibited the neuronal death …

ROS detoxification and proinflammatory cytokines are linked by p38 MAPK signaling in a model of mature astrocyte activation

A Nahirnyj, I Livne-Bar, X Guo, JM Sivak - PloS one, 2013 - journals.plos.org
… Here we describe a system for rapid culture of mature astrocytes … When primary astrocytes
were exposed to reactive oxygen … Additionally, multiplex cytokine profiling detected p38 MAPK-…

Toll-like receptors control p38 and JNK MAPK signaling pathways in rat astrocytes differently, when cultured in normal or high glucose concentrations

DV Chistyakov, NV Azbukina, AA Astakhova… - Neurochemistry …, 2019 - Elsevier
… Moreover, the inhibitors of p38 MAPK or JNK did not influence the … inhibition with SP600126
completely abolished the LPS-mediated decrease of PPARγ, while the p38 MAPK inhibitor

Activated microglia decrease histone acetylation and Nrf2-inducible anti-oxidant defence in astrocytes: restoring effects of inhibitors of HDACs, p38 MAPK and GSK3β

F Correa, C Mallard, M Nilsson, M Sandberg - Neurobiology of disease, 2011 - Elsevier
… shown that inhibition of p38 MAPK signalling with SB203580 (20 μM) inhibited the
decrease in Nrf2 and γGCL-M protein levels and reduced H 2 O 2 induced death in astrocyte-rich …

Delayed and differential induction of p38 MAPK isoforms in microglia and astrocytes in the brain after transient global ischemia

CS Piao, Y Che, PL Han, JK Lee - Molecular brain research, 2002 - Elsevier
… of SB203580, an inhibitor of p38 MAPK, reduced the … and expression of the two p38 MAPK
isoforms, p38α and p38β, … -immunoreactive cells resembled reactive astrocytes, in which the …

Gypenoside IX suppresses p38 MAPK/Akt/NFκB signaling pathway activation and inflammatory responses in astrocytes stimulated by proinflammatory mediators

X Wang, L Yang, L Yang, F Xing, H Yang, L Qin, Y Lan… - Inflammation, 2017 - Springer
… In present study, the anti-inflammatory effects of GP IX were investigated in reactive astrocytes
p38 MAPK signaling pathways, suggesting that GP IX inhibited the activation of astrocytes

Interactions between Sirt1 and MAPKs regulate astrocyte activation induced by brain injury in vitro and in vivo

D Li, N Liu, HH Zhao, X Zhang, H Kawano, L Liu… - Journal of …, 2017 - Springer
astrocyte activation induced by IL-1β stimulation in vitro and traumatic brain injury in vivo;
inhibition of ERK, JNK, or p38MAPK … cell hypertrophy to attenuate the astrocyte activation; Sirt1 …