… suppressor functions as well as to gain of oncogenic transformation capabilities. In this …
p53 gene in various glial tumors, contrast that with the spectra described in other human tumor …

… how the loss of p53 in parallel with deregulation of growth factor signaling pathways promotes
brain tumor development. Finally, we discuss how the reactivation of p53 in brain tumor …

… tumors. Here, we review the molecular and physiological functions of p53 and examine how
their loss favors brain tumor … tumor formation and allowed the development of therapies for …

… However, p53 … , p53 mutations are frequently identified in brain tumors, especially
glioblastomas. Mechanisms underlying p53 inactivation in brain tumor cells include disruption of p53 …

… The spec trum of mutations which we observed in our panel of nonastrocytic brain tumors,
mainly G to A transitions, is consistent with the reports of brain tumors studied by others (24, 25…

… modification the function of the wild type p53 protein can … functional modulation of p53 gene
in human brain tumor development. Keywords : Brain tumors, Cell-cycle, Conformation, p53 …

… p53 to neurodegenerative diseases and brain cancers, and we document the various
strategies to interfere with p53 … These observations indicated that p53 likely behaved as a tumor …

… functions. Furthermore, we discuss the most promising approaches of potential brain tumor
therapy, including an adenovirus-mediated p53 … of p53 activity when the wild-type p53 is …

… p53 functions in tumor suppression and review its involvement in the formation of brain tumors…
Here, we review the molecular and biological functions of p53 and examine how their loss …

… brain tumor initiating cells. Here, we show for the first time, that absence of p53 renders brain
tumor … results with regard to the effect of p53 on TMZ sensitivity because GBMs contain two …