Is there a specific mutation of p53 gene due to radon exposure? A systematic review

A Ruano-Ravina, MJ Faraldo-Vallés… - International journal of …, 2009 - Taylor & Francis
radon exposure and TP53 mutations in lung tumours, and to establish whether mutation AGG
… →ATG MET in codon 249 of lung tumours can be considered specific of radon exposure. …

The cellular and molecular carcinogenic effects of radon exposure: a review

A Robertson, J Allen, R Laney, A Curnow - International journal of …, 2013 - mdpi.com
… , analysed 72 lung cancers and found no correlation between variation in radon exposure
and either TP53 mutations or p53 expression, although the number of sequenced samples for …

p53 Mutations in Lung Cancer Associated with Residential Radon Exposure

A Yngveson, C Williams, A Hjerpe, J Lundeberg… - … Biomarkers & Prevention, 1999 - AACR
mutation patterns in lung tumors among underground miners have been indicated, suggesting
radon… association between residential radon exposure and p53 mutations in lung tumors, …

p53 mutation hotspot in radon-associated lung cancer

JA Taylor, MA Watson, RY Michels, G Saccomanno… - The Lancet, 1994 - Elsevier
… whether the p53 codon 249 mutation is present in adenocarcinomas and small cell cancers
from uranium miners, in the lung cancers of people with low-dose exposures (as in radon-…

Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners

KH Vahakangas, RA Metcalf, JA Welsh, WP Bennett… - The Lancet, 1992 - Elsevier
… miners exposed to radon and … Mutations of p53 attributed to ultraviolet light10 and to
aflatoxin B111 have been reported. This report describes the mutational spectrum of p53 in radon-…

[HTML][HTML] … of the relationship between p53 immunohistochemical expression and risk factors for lung cancer, with special emphasis on residential radon exposure

A Ruano-Ravina, R Pérez-Becerra, M Fraga… - Annals of oncology, 2008 - Elsevier
radon exposure and p53 expression through p53 immunohistochemistry in this case series.
Furthermore, no mutations were … These results show that radon exposure might not exert its …

[HTML][HTML] Novel genetic associations between lung cancer and indoor radon exposure

JR Choi, SB Koh, SY Park, HR Kim, H Lee… - Journal of Cancer …, 2017 - ncbi.nlm.nih.gov
… Additionally, TP53 mutations have also been highlighted … Moreover, other recent articles
found TP53 mutations and … Radon is the second leading cause of LCINS.15,16 Feasibly, …

TP53 mutations in workers exposed to occupational carcinogens

K Vähäkangas - Human mutation, 2003 - Wiley Online Library
… Screening for putative radon-specific p53 mutation hotspot in German uranium miners.
Lancet 346:121. Bennett WP, Hussain SP, Vähäkangas KH, Khan MA, Shields PG, Harris CC. …

Radon and lung carcinogenesis: mutability of p53 codons 249 and 250 to 238Pu alpha-particles in human bronchial epithelial cells.

SP Hussain, CH Kennedy, P Amstad, H Lui… - …, 1997 - academic.oup.com
p53 mutation spectrum from lung cancer associated with radon exposure and tobacco
smoking. (The pi diagram has been drawn using a p53 mutation database [Hollstein et al. (34)] …

Indoor radon exposure increases tumor mutation burden in never-smoker patients with lung adenocarcinoma

SM Lim, JW Choi, MH Hong, D Jung, CY Lee, SY Park… - Lung Cancer, 2019 - Elsevier
… To investigate the effect of indoor radon exposure, we estimated the cumulative exposure
to indoor radon … We also found that TP53 mutation was more common in those with high-radon