[HTML][HTML] Significant determinants of mouse pain behaviour

MS Minett, N Eijkelkamp, JN Wood - PloS one, 2014 - journals.plos.org
… for conflicting data on the pain phenotypes of knockout mice to be generated by … mouse
pain behaviour that are often overlooked, which may help explain discrepancies in the pain

Measuring pain in the (knockout) mouse: big challenges in a small mammal

SG Wilson, JS Mogil - Behavioural brain research, 2001 - Elsevier
… in the production and characterization of knockout mice and other defined mutants should
contribute vastly to our understanding of biology in general, and pain research in particular. At …

Usefulness of knockout mice to clarify the role of the opioid system in chronic pain

R Maldonado, JE Baños… - British journal of …, 2018 - Wiley Online Library
… chronic pain. Behavioural data obtained in these chronic pain models are discussed …
the peculiarities of the behavioural phenotype of each line of knockout mice. These studies …

Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour

TJS Shi, X Hua, X Lu, S Malkmus… - European Journal of …, 2006 - Wiley Online Library
… hyperalgesia (Kerr et al., 2001), whereas in the GalR2–/– mice (loss distributed over all
size categories of DRG NPs) we could only see minor effects in the pain behavioural tests. …

Reduced inflammatory and neuropathic pain and decreased spinal microglial response in fractalkine receptor (CX3CR1) knockout mice

AA Staniland, AK Clark, R Wodarski… - Journal of …, 2010 - Wiley Online Library
… CX3CR1 knockout (KO) mice to examine pain behaviour in the absence of FKN signalling.
Naive CX3CR1 KO mice had normal responses to acute noxious stimuli. However, KO mice

Neuropathic pain is enhanced in δ‐opioid receptor knockout mice

X Nadal, JE Baños, BL Kieffer… - European Journal of …, 2006 - Wiley Online Library
pain in DOR knockout mice and wild-type littermates. The behavioural manifestations of
neuropathic pain … The behavioural responses were determined under basal conditions and 3 (D3…

Development and expression of neuropathic pain in CB1 knockout mice

A Castañé, E Célérier, M Martín, C Ledent… - …, 2006 - Elsevier
… the behavioural manifestations of neuropathic pain in both WT and CB1 KO mice exposed
… Our results reveal that CB1 cannabinoid receptor knockout mice do not show altered pain

Exploring the role of nociceptor-specific sodium channels in pain transmission using Nav1. 8 and Nav1. 9 knockout mice

S Leo, R D'Hooge, T Meert - Behavioural brain research, 2010 - Elsevier
… channels in different pain states. Using Na v 1.8 and Na v 1.9 knockout mice, we found …
play a role in cold allodynia in neuropathic pain conditions. Moreover, genetic deletion of Na v …

Opioids: first lessons from knockout mice

BL Kieffer, BL Kieffer - Trends in pharmacological sciences, 1999 - cell.com
… to pain, stress and emotions when activated by endogenous opioid peptides. Recently, mice
… Observations on mutant mice have shed new light on the mode of action of opioids, opioid …

Inflammatory pain is enhanced in delta opioid receptor‐knockout mice

C Gavériaux‐Ruff, LA Karchewski… - European Journal of …, 2008 - Wiley Online Library
… delta receptors inhibit inflammatory pain when activated either … pain in delta‐receptor
knockout mice. The delta receptor definitely represents a promising target for treating chronic pain