Role of Wnt/β-catenin signaling in drug resistance of pancreatic cancer

J Cui, W Jiang, S Wang, L Wang… - Current pharmaceutical …, 2012 - ingentaconnect.com
… of pancreatic cancer. Conceivably, the dysregulation of Wnt/β-catenin signaling pathway is
involved in pancreatic cancer … Though researchers have proven it in some other cancer types, …

Therapeutic potential of targeting the Wnt/βcatenin pathway in the treatment of pancreatic cancer

SA Javadinia, S Shahidsales… - Journal of Cellular …, 2019 - Wiley Online Library
… , including pancreaticβcatenin, and activation of target genes leads to a more aggressive
phenotype, suggesting its potential value as a therapeutic target in the treatment of pancreatic

[HTML][HTML] β-catenin blocks Kras-dependent reprogramming of acini into pancreatic cancer precursor lesions in mice

JP Morris, DA Cano, S Sekine… - The Journal of …, 2010 - Am Soc Clin Investig
… (ADM) and pancreatic cancer precursor lesion formation by blocking acinar regeneration
following acute pancreatitis. Our results indicate that β-catenin is required for efficient acinar …

[HTML][HTML] Oncogenic function of ATDC in pancreatic cancer through Wnt pathway activation and β-catenin stabilization

L Wang, DG Heidt, CJ Lee, H Yang, CD Logsdon… - Cancer cell, 2009 - cell.com
… of β-catenin. Besides highlighting ATDC as a potential therapeutic target … pancreatic
cancer, our studies have defined a mechanism for activating Wnt/β-catenin signaling in cancer

[HTML][HTML] Wnt/β-catenin signaling: the culprit in pancreatic carcinogenesis and therapeutic resistance

M Ram Makena, H Gatla, D Verlekar… - International journal of …, 2019 - mdpi.com
… In this review, we have summarized the role of Wnt signaling in pancreatic cancer and
suggested future directions to enhance the survival of pancreatic cancer patients. …

[HTML][HTML] TOP2A induces malignant character of pancreatic cancer through activating β-catenin signaling pathway

Y Pei, X Yin, X Liu - Biochimica et Biophysica Acta (BBA)-Molecular Basis …, 2018 - Elsevier
… Knockdown of TOP2A in pancreatic cancer cell lines inhibited cell … -catenin pathway in
pancreatic cancer. Mechanistically, we demonstrated TOP2A acts as a co-activator ofβ-catenin

[HTML][HTML] Differentiation therapy targeting the β-catenin/CBP interaction in pancreatic cancer

P Manegold, KKY Lai, Y Wu, JL Teo, HJ Lenz… - Cancers, 2018 - mdpi.com
… in human pancreatic cancer cells and in … /β-catenin interaction in pancreatic cancer; and
that ICG-001 specific antagonism of the CBP/β-catenin interaction sensitizes pancreatic cancer

[HTML][HTML] β-Catenin expression is associated with cell invasiveness in pancreatic cancer

JN Nan, OR Kim, MA Lee - The Korean journal of internal medicine, 2019 - ncbi.nlm.nih.gov
… the role of β-catenin in invasion in pancreatic cancer. … As reported in previous studies, the
Wnt/β-catenin pathway can … Wnt/β-catenin signaling pathway by using pancreatic cancer cell …

[HTML][HTML] β-catenin up-regulates the expression of cyclinD1, c-myc and MMP-7 in human pancreatic cancer: relationships with carcinogenesis and metastasis

YJ Li, ZM Wei, YX Meng, XR Ji - World journal of gastroenterology …, 2005 - ncbi.nlm.nih.gov
… in pancreatic cancer, and the results were conflicting[7,23-28]. … of pancreatic cancer, we
detected expression of β-catenin, cyclinD1, c-myc and MMP-7 in normal pancreas, pancreatic

Inflammation promotes progression of pancreatic cancer through WNT/β-catenin pathway-dependent manner

R Ren, J Yu, Y Zhang, SF Wang, X Guo, M Shen… - Pancreas, 2019 - journals.lww.com
… in the pancreatic cancer progression is still far from defined. … of pancreatic tumor immune
escape, identified WNT/β-catenin … process of inflammation carcinogenesis in pancreatic cancer. …