… These pre-malignant lesions occur in pancreatic ductal cells and are further characterized
as three different histological subtypes for which there are clear classifying guidelines. These …

… The cells responsible for producing the stromal reaction in pancreatic cancer are activated
pancreatic stellate cells (PSCs, the key effector cells in pancreatic fibrogenesis). In vitro and in …

… active during development, such as WNT, SHH and NOTCH, are also reactivated in some
pancreatic cancers 31 . … The immune cell complement in pancreatic cancer includes T cells (a …

… Therefore, antifibrogenic therapies targeting pancreatic cancer cell-stellate cell interactions
may open a new avenue of treatment in PDAC. Interestingly, it has recently been observed …

… Pancreatic cancer is a highly fatal disease with a 5-year survival rate … cancer is still localised.
High quality computed tomography with intravenous contrast using a dual phase pancreatic …

… biology of pancreatic cancer will we be in a position to effectively diagnose, prevent, and
treat this disease. Close to 100% of patients with pancreatic cancer develop metastases and …

… A PubMed search was carried out for the terms ‘pancreas cancer’ OR ‘pancreatic cancer’,
AND ‘pancreatic stellate cells’, NOT ‘hepatic stellate cells’. All studies were screened and …

… like cells found in the activated stroma of pancreatic cancer significantly … Pancreatic cancer
cells activate the stellate cells around them (b, immunohsitochemistry staining of stellate cells …

… pancreatic cancer cells secrete biologically active VEGF and whether blocking VEGF
expression and secretion suppresses the tumorigenicity of PANC-1 pancreatic cancer cells. …

… The FRAP-p70 s6K signaling pathway was found to be constitutively phosphorylated/active
in MiaPaCa-2 and Panc-1 human pancreatic cancer cells and a pancreatic cancer tissue …