… ; a pro-apoptotic tumor suppressor protein) has been shown to be associated with cisplatin
resistance in pancreatic cancer cells through upregulation of Akt/PI3K signaling [33]. PI3K/Akt/…

… have provided strong evidence on the role of PI3K/AKT/mTOR pathway in PDAC, clinical …
PI3K/AKT/mTOR pathway could provide valuable assets for treatment of pancreatic cancer …

… However, it does not necessary imply that other mechanisms are not involved in PI3K/Akt/mTOR
hyperactivation in pancreatic cancer. PTEN loss mainly occurs through hyper …

… of the tumor cells, it failed to significantly improve the outcome of pancreatic carcinoma patients.
… κB (NF-κB) and PI3K/Akt in the resistance of five pancreatic carcinoma cell lines towards …

… pancreatic cancer patients. In this review, we focus on PI3K/AKT/mTOR inhibitors that have
shown great anti-tumor potential in studies performed on xenograft models and pancreatic …

… secretion level of VEGF in pancreatic cancer through the active PI3K/Akt/VEGF/eNOS signaling
… report that PTEN siRNA modulates tumor angiogenesis in pancreatic cancer cell in vitro. …

… Akt via … Akt phosphorylation and inhibits the transcription of PI3K, reducing its activation.
These results suggest that LAMB3 promotes tumor invasion via Akt activation through the PI3K …

… Our findings indicated that scoparone inhibits pancreatic cancer cell proliferation, migration,
and invasion, and induced cell cycle arrest and apoptosis through the PI3K/Akt signaling …

… study provided the molecular mechanism of PI3K/Akt pathway and Plk1 in the pancreatic
cancer cell proliferation and apoptosis, which may benefit for the therapy of pancreatic cancer. …

… of PI3K/Akt/mTOR and Shh pathways may be beneficial for the treatment of pancreatic
cancer. … In summary, our findings suggest that combined inhibition of PI3K/Akt/mTOR and Shh …