… the proliferation, apoptosis and autophagy of human pancreatic cancer (PC) cell lines in vitro
… to establish an orthotopic pancreatic tumor model in nude mice. Tumor‑bearing nude mice …

… of the PI3K/Akt pathway in pancreatic cancer cells as demonstrated by the reduction of the
Akt … Finally, α-mangostin significantly inhibited the growth of BxPc-3 tumor mouse xenografts. …

… ‑9/3 activation in the pancreatic cancer cells. Using siRNA against FOXO1, and Akt inhibitor
and … by inhibition of phosphoinositide 3‑kinase/Akt signaling, leading to cell cycle arrest and …

… pancreatic cancer cell autophagy by inhibiting the PI3K/AKT/… PI3K/Akt/mTOR signaling
pathway in pancreatic cancer. The autophagy declines the ROS production of pancreatic cancer. …

… 24 h reduced the migration of pancreatic cancer cells without the addition of SOD (… pancreatic
cancer through suppression of the PI3K/Akt/NF-κB signaling pathway in pancreatic cancer …

… may influence pancreatic cancer cell processes via the PI3K/Akt pathway. … PI3K/Akt pathway
by western blotting. Following rAd-shGirdin infection, levels of p-PI3K (Thy 508) and p-Akt (…

… To examine the relevance of CUX1 as a downstream effector in PI3K/Akt-induced resistance
to apoptosis, we modulated CUX1 expression either directly by siRNA or by inhibiting …

… via inhibition of PI3K/Akt/mTOR pathway … pancreatic cancer contains pancreatic CSCs, we
sought to examine the molecular mechanism by which ROT induces autophagy in pancreatic …

… , and could activate PI3K/Akt pathway by interacting with the SH3 domain of PI3K regulatory
… PAK4 and PI3K/Akt pathway. Western blot analysis showed that the levels of PAK4, p-Akt, p-…

… In this study, we tested the hypothesis that Akt is a key downstream target by … pancreatic
cancer cells and that suppression of Notch3/PI3K/Akt pathway would enhance pancreatic cancer …