… expression and activity of the PI3K and AKT are upregulated in pancreatic cancer cells, which
is … that the PI3K/AKT signaling pathway is a key regulatory pathway not only in pancreatic …

… recently found that activated PI3K/Akt signaling results in a … of PI3K/Akt/mTOR signaling
leads to acceleration of PDAC progression in mouse. Similarly, in humans, activation of PI3K/Akt/…

… the PI3K-AKT pathway to promote the tumorigenesis and metastasis of pancreatic cancer. …
growth and invasion abilities of pancreatic cancer cells dependent or independent on PI3K-…

… We demonstrated for the first time that Rhein can inhibit the PI3K/AKT pathway and display
a … the PI3K/AKT pathway in various tumor cells treated with natural anti-tumor drugs 46 , 47 . …

… PI3K/AKT, ERK and EMT signaling pathways. To further investigate the specific functions
of ELF3 in pancreatic cancer… the progression of pancreatic cancer via the PI3K/AKT/Notch/EMT …

… the Warburg effect in pancreatic cancer cells via the regulation of PI3K/AKT/mTOR signaling…
the therapeutic effectiveness of Evr against pancreatic cancer growth was greater in GEM …

… cancer cells 11,12 . These findings suggest that simultaneous inhibition of the EGFR and
PI3K/AKT … enhance erlotinib sensitivity in pancreatic cancers with aberrant PI3K/AKT signaling. …

… Together, our results establish that the PI3k/AKT pathway is constitutively activated in a
majority of human pancreatic cancer cell lines and establish that the pathway is a promising …

… fisetin obviously dampens pancreatic cancer progress in vitro … repressed pancreatic cancer
via explicitly targeting PI3K/AKT/… a prospective anti-cancer drug for pancreatic cancer, as well …

… with the PI3K/AKT signaling pathway in the occurrence and development of pancreatic cancer.
Thus, … in pancreatic cancer cells, and to explore potential mechanisms associated with the …