[HTML][HTML] Combination of PI3K/Akt pathway inhibition and Plk1 depletion can enhance chemosensitivity to gemcitabine in pancreatic carcinoma

Y Mao, L Xi, Q Li, S Wang, Z Cai, X Zhang, C Yu - Translational Oncology, 2018 - Elsevier
… the Akt expression in pancreatic cancer (P < .001) while PI3K inhibitor LY294002 can reverse
this process (P < .001). (D) Akt … (E) Pancreatic cancer cell apoptosis was detected by Flow …

IGF-1 mediates PTEN suppression and enhances cell invasion and proliferation via activation of the IGF-1/PI3K/Akt signaling pathway in pancreatic cancer cells

J Ma, H Sawai, Y Matsuo, N Ochi, A Yasuda… - Journal of Surgical …, 2010 - Elsevier
… of pancreatic cancer cells. We suggest that interfering with the functions of IGF-1/PI3K/Akt/NF…
кB might be a novel therapeutic approach to inhibit aggressive spread of pancreatic cancer. …

[HTML][HTML] AKT inhibition is associated with chemosensitisation in the pancreatic cancer cell line MIA-PaCa-2

BN Fahy, M Schlieman, S Virudachalam… - … journal of cancer, 2003 - nature.com
… Therefore, given the preliminary cellular studies that demonstrate that the inhibition of
PI3K/AKT sensitises pancreatic cancer to the apoptotic effect of chemotherapy, we sought to …

[HTML][HTML] Epidermal growth factor induces HCCR expression via PI3K/Akt/mTOR signaling in PANC-1 pancreatic cancer cells

Z Xu, Y Zhang, J Jiang, Y Yang, R Shi, B Hao, Z Zhang… - Bmc Cancer, 2010 - Springer
… in cervical cancer tissues, but also in several other cancers … role of HCCR-1 in
pancreatic cancer development. Here in this … for pancreatic cancer via EGF mediated-PI3K/Akt/mTOR …

Activation of the PI3K/Akt pathway mediates bone morphogenetic protein 2-induced invasion of pancreatic cancer cells Panc-1

X Chen, J Liao, YB Lu, XH Duan, WJ Sun - Pathology & Oncology …, 2011 - Springer
… of the PI3K/Akt pathway in invasiveness of pancreatic cancer … In the present study, we
explored the role of the PI3K/Akt … of pancreatic cancer through the recruitment of the PI3K/Akt

… the angiogenesis and growth of human pancreatic cancer by targeting vascular endothelial growth factor receptor 2‐mediated PI3K/Akt/mTOR signaling pathway

L He, Y Wu, L Lin, J Wang, Y Wu, Y Chen, Z Yi… - Cancer …, 2011 - Wiley Online Library
pancreatic tumor angiogenesis and tumor growth by targeting the VEGFR2-mediated PI3K/Akt/…
hispidulin could be a potential drug candidate for cancer prevention and cancer therapy. …

[HTML][HTML] MicroRNA‑23b‑3p promotes pancreatic cancer cell tumorigenesis and metastasis via the JAK/PI3K and Akt/NF‑κB signaling pathways

Y Zhang, D Chen, G Zhang, X Wu… - Oncology …, 2020 - spandidos-publications.com
… could enhance tumorigenesis and induce tumor development in a variety of … PI3K/Akt
signaling has been frequently upregulated in various types of cancer (20), plays a key role in tumor

[PDF][PDF] MiR-19 enhances pancreatic cancer progression by targeting PTEN through PI3K/AKT signaling pathway.

GF Zhang, JM Zhong, L Lin… - European Review for …, 2020 - europeanreview.org
… /protein kinase B (PI3K/AKT) signaling pathway. CONCLUSIONS: … PI3K/AKT signaling
pathway by targeting PTEN, which provided a potential therapeutic target for pancreatic cancer

[HTML][HTML] Shikonin promotes autophagy in BXPC‑3 human pancreatic cancer cells through the PI3K/Akt signaling pathway

S Shi, H Cao - Oncology Letters, 2014 - spandidos-publications.com
… the protein expression of p62, PI3K, Akt, p‑PI3K and p‑Akt was decreased. These findings
… , PI3K/Akt signaling molecules may have potential therapeutic targets in pancreatic cancer (…

A blockade of PD-L1 produced antitumor and antimetastatic effects in an orthotopic mouse pancreatic cancer model via the PI3K/Akt/mTOR signaling pathway

L Zhao, C Li, F Liu, Y Zhao, J Liu, Y Hua… - OncoTargets and …, 2017 - Taylor & Francis
… /mTOR signaling pathway, we examined the levels of PTEN, PI3K, Akt, and mTOR mRNA
expression in pancreatic cancer tissue and spontaneous liver metastases after treatment with …