… /mTOR signaling pathway, we examined the levels of PTEN, PI3K, Akt, and mTOR mRNA
expression in pancreatic cancer tissue and spontaneous liver metastases after treatment with …

… BC06 on phosphorylation of Akt and expression of PI3K and NF-… Akt (S473) and also
decreased PI3K (P85α), PI3K (P110α), and NF-KB in a dose-dependent manner (Figure 4B). As Akt …

… -inositol 3-kinase (PI3K)/serine-threonine kinase (AKT) signal transduction that can be …
the antitumor effect of mTOR in human pancreatic cancer SW1990 cells and to elucidate the …

… AKT and ERK1/2 results in tumor inhibition. Other studies similarly reported that inhibition
of the AKT/mTOR pathway promotes apoptosis and autophagy of pancreatic cancer cells (19), …

… Our results demonstrate that perifosine is the targeted anti-PI3K/Akt antitumor agent
demonstrating the most potent growth inhibitory effects in a panel of human PDAC cells …

… Effect of RLIP76 antisense on PI3K and Akt signaling in pancreatic cancer cells: RLIP76
antisense caused inhibition of PI3K/Akt pathway in BxPC-3 and Panc-1 cells. Cells were treated …

… MiR-139-5p could regulate and affect the protein expression of P13K and Akt associated …
suppress PANC tumor growth and the expressions of SLC7A11, p-PI3K, p-Akt in tumor tissues. …

… to possess potent anti-tumor and anti-inflammatory properties, … likely be related to the
PI3K/AKT signaling pathway and EGFR TKI … to ERL via inhibiting PI3K/AKT and EGFR signaling. …

… affected pancreatic cancer (PC) chemoresistance by regulating PI3K/Akt/mTOR signaling. …
Therefore, this investigation was intended to disclose the interaction of SRPX2 and PI3K/Akt/…

… expression in human pancreatic cancer, we analysed normal human pancreatic tissues
and tumour tissues from patients with PDAC. First, we identified normal pancreatic and tumour …