[HTML][HTML] Cucurbitacin B and SCH772984 exhibit synergistic anti-pancreatic cancer activities by suppressing EGFR, PI3K/Akt/mTOR, STAT3 and ERK signaling
J Zhou, T Zhao, L Ma, M Liang, YJ Guo, LM Zhao - Oncotarget, 2017 - ncbi.nlm.nih.gov
… In this study, we demonstrate for the first time that CuB inhibits pancreatic cancer cell
proliferation by interfering with EGFR levels and downstream signaling of PI3K/Akt/mTOR and …
proliferation by interfering with EGFR levels and downstream signaling of PI3K/Akt/mTOR and …
… induces cell cycle arrest and autophagy and suppresses epithelial to mesenchymal transition involving PI3K/Akt/mTOR-mediated pathway in human pancreatic cancer …
F Wang, Q Wang, ZW Zhou, SN Yu, ST Pan… - Drug design …, 2015 - Taylor & Francis
… of pancreatic cancer is unclear. This study aimed to examine the pancreatic cancer cell …
and investigate the underlying mechanism in human pancreatic cancer PANC-1 and BxPC-…
and investigate the underlying mechanism in human pancreatic cancer PANC-1 and BxPC-…
miRNA-93-5p promotes gemcitabine resistance in pancreatic cancer cells by targeting the PTEN-mediated PI3K/Akt signaling pathway
Y Wu, W Xu, Y Yang, Z Zhang - Annals of Clinical & Laboratory …, 2021 - Assoc Clin Scientists
… by suppression of PI3K/Akt signaling. For this, LY294002 as a specific PI3K inhibitor was
employed … Our results showed that inhibition of the PI3K/Akt pathway by LY294002 significantly …
employed … Our results showed that inhibition of the PI3K/Akt pathway by LY294002 significantly …
… the insensitivity and potentiates the antitumor effect of gemcitabine through abrogation of Notch1, PI3K/Akt/mTOR regulated signaling pathways in pancreatic cancer
G Mu, L Zhang, H Li, Y Liao, H Yu - Digestive diseases and sciences, 2015 - Springer
… kinase of the PI3K kinase family and is supposed to be a key effector of the PI3K/Akt/mTOR …
We observed the activation of Akt/mTOR and S6 ribosomal protein in pancreatic cancer …
We observed the activation of Akt/mTOR and S6 ribosomal protein in pancreatic cancer …
[HTML][HTML] EG-VEGF silencing inhibits cell proliferation and promotes cell apoptosis in pancreatic carcinoma via PI3K/AKT/mTOR signaling pathway
X Yan, Y Hui, Y Hua, L Huang, L Wang, F Peng… - Biomedicine & …, 2019 - Elsevier
… -expression of EG-VEGF in pancreatic carcinoma tissues and cells, and … PI3K/AKT/mTOR
pathway. Thus, EG-VEGF may become an essential target for the therapy of pancreatic cancer …
pathway. Thus, EG-VEGF may become an essential target for the therapy of pancreatic cancer …
[HTML][HTML] HTR1D functions as a key target of HOXA10-AS/miR-340-3p axis to promote the malignant outcome of pancreatic cancer via PI3K-AKT signaling pathway
W Wu, Q Li, Z Zhu, C Li, P Lu, X Zhou… - … journal of biological …, 2022 - ncbi.nlm.nih.gov
… level of AKT, a key gene in the PI3K-AKT signaling pathway, … the effects of HTR1D on
pancreatic cancer using MK-2206, … pancreatic cancer partly via the PI3K-AKT signaling pathway. …
pancreatic cancer using MK-2206, … pancreatic cancer partly via the PI3K-AKT signaling pathway. …
Doxycycline Inhibits Cancer Stem Cell-Like Properties via PAR1/FAK/PI3K/AKT Pathway in Pancreatic Cancer
H Liu, H Tao, H Wang, Y Yang, R Yang, X Dai… - Frontiers in …, 2021 - frontiersin.org
… Doxycycline inhibits the growth of pancreatic cancer … pancreatic cancer cells via the
FAK/PI3K/AKT pathway. Doxycycline inhibits the pancreatic cancer through the PAR1/FAK/PI3K/AKT …
FAK/PI3K/AKT pathway. Doxycycline inhibits the pancreatic cancer through the PAR1/FAK/PI3K/AKT …
[HTML][HTML] Targeting the PI3K-AKT-mTOR signaling network in cancer
KH Khan, TA Yap, L Yan… - Chinese journal of cancer, 2013 - ncbi.nlm.nih.gov
… AKT-mammalian target of rapamycin (PI3K-AKT-mTOR) pathway is a frequently hyperactivated
pathway in cancer and is important for tumor … , renal, and pancreatic cancers. However, …
pathway in cancer and is important for tumor … , renal, and pancreatic cancers. However, …
PI3K/Akt signalling pathway and cancer
JÁF Vara, E Casado, J de Castro, P Cejas… - Cancer treatment …, 2004 - Elsevier
… , we discuss PI3K/Akt pathway components and functions as well as its alteration in cancer
and … In pancreatic cancer cell lines, PI3K/Akt pathway has been found to be implicated in …
and … In pancreatic cancer cell lines, PI3K/Akt pathway has been found to be implicated in …
Par-4 downregulation confers cisplatin resistance in pancreatic cancer cells via PI3K/Akt pathway-dependent EMT
J Tan, Y You, T Xu, P Yu, D Wu, H Deng, Y Zhang… - Toxicology letters, 2014 - Elsevier
… in pancreatic cancer cells. Our results demonstrate that Par-4 downregulation confers CDDP
resistance in pancreatic cancer cells probably via induction of PI3K/Akt … in pancreatic cancer …
resistance in pancreatic cancer cells probably via induction of PI3K/Akt … in pancreatic cancer …