KRAS: the critical driver and therapeutic target for pancreatic cancer
… all PDAC, this cancer type is arguably the most RAS-addicted cancer. With substantial …
Cancer Institute identified targeting KRAS as one of four major priorities for pancreatic cancer …
Cancer Institute identified targeting KRAS as one of four major priorities for pancreatic cancer …
New therapeutic targets in pancreatic cancer
E Lai, M Puzzoni, P Ziranu, A Pretta, V Impera… - Cancer treatment …, 2019 - Elsevier
… high expression of TP63 and its target genes as key features in adenosquamous pancreatic
tumours. Furthermore, hypermethylation and down-regulation of genes involved in the …
tumours. Furthermore, hypermethylation and down-regulation of genes involved in the …
New biomarkers and targets in pancreatic cancer and their application to treatment
E Costello, W Greenhalf, JP Neoptolemos - … reviews Gastroenterology & …, 2012 - nature.com
… Other EGFR and HER2 targeted therapies, including the antibodies cetuximab and …
benefit in patients with pancreatic cancer, as was also true for targeting of vascular endothelial …
benefit in patients with pancreatic cancer, as was also true for targeting of vascular endothelial …
[HTML][HTML] Novel therapeutic targets for pancreatic cancer
SC Tang, YC Chen - World journal of gastroenterology: WJG, 2014 - ncbi.nlm.nih.gov
… and motility of pancreatic cancer cell, future … targeted therapy with current anti pancreatic
cancer drugs. CTHRC1 appears as a promising target in sequestering pancreatic cancer from …
cancer drugs. CTHRC1 appears as a promising target in sequestering pancreatic cancer from …
[HTML][HTML] Critical role of NF-κB in pancreatic cancer
… in pancreatic cancer cells and promotes tumorigenesis and metastasis. … targeting NF-κB
in conjunction with either classical chemotherapy, such as gemcitabine or other targeted …
in conjunction with either classical chemotherapy, such as gemcitabine or other targeted …
Autophagy as a therapeutic target in pancreatic cancer
… These changes contribute to create a state of autophagy dependence, which can be
therapeutically targeted. This concept was further validated in several pancreatic cancer cell lines …
therapeutically targeted. This concept was further validated in several pancreatic cancer cell lines …
LASP1 is a HIF1α target gene critical for metastasis of pancreatic cancer
T Zhao, H Ren, J Li, J Chen, H Zhang, W Xin, Y Sun… - Cancer research, 2015 - AACR
… Our previous study indicated HIF1 as a critical transcriptional factor in pancreatic cancer cell
… of LASP-1 in pancreatic cancer cells, we used specific siRNAs targeting HIF1α to effectively …
… of LASP-1 in pancreatic cancer cells, we used specific siRNAs targeting HIF1α to effectively …
Pancreatic cancer stroma: an update on therapeutic targeting strategies
… Pancreatic cancer cells induce a desmoplastic response within the tumour stroma by …
desmoplastic reaction is critical in PDAC pathogenesis, which makes therapeutic targeting of ECM …
desmoplastic reaction is critical in PDAC pathogenesis, which makes therapeutic targeting of ECM …
Biomarkers and targeted therapy in pancreatic cancer
F Karandish, S Mallik - Biomarkers in cancer, 2016 - journals.sagepub.com
… importance in targeted drug delivery for pancreatic cancers. … -1, and SU86.86 pancreatic
cancer cell lines. ABCC3 is an … of pancreatic cancer and may be used for cell surface-targeted …
cancer cell lines. ABCC3 is an … of pancreatic cancer and may be used for cell surface-targeted …
[HTML][HTML] Targeted therapies for pancreatic cancer
SA Danovi, HH Wong, NR Lemoine - British medical bulletin, 2008 - ncbi.nlm.nih.gov
… pancreatic cancer at early stages due to the non-specific presenting symptoms, the inaccessibility
of the pancreas … only curative option for patients with pancreatic cancer, but at present, …
of the pancreas … only curative option for patients with pancreatic cancer, but at present, …
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