Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer
E Giovannetti, V Mey, S Nannizzi, G Pasqualetti… - Molecular Cancer …, 2006 - AACR
… Due to the delay of clinical diagnosis, pancreatic cancer is often … drugs and has produced
unsatisfactory results. Gemcitabine is now the standard drug for advanced pancreas cancer (4)…
unsatisfactory results. Gemcitabine is now the standard drug for advanced pancreas cancer (4)…
Metformin influences drug sensitivity in pancreatic cancer cells
S Candido, SL Abrams, L Steelman… - Advances in biological …, 2018 - Elsevier
… Metformin, by itself, was not effective at suppressing growth of the pancreatic cancer … drugs
used to treat pancreatic cancer (eg., gemcitabine, cisplatin, 5-fluorouracil) and other cancer …
used to treat pancreatic cancer (eg., gemcitabine, cisplatin, 5-fluorouracil) and other cancer …
Overcoming drug resistance in pancreatic cancer
J Long, Y Zhang, X Yu, J Yang, DG LeBrun… - Expert opinion on …, 2011 - Taylor & Francis
… gemcitabine killing of gemcitabine-sensitive pancreatic cancer cells such as BxPC-3 cells
… in gemcitabine-sensitive but not gemcitabine-resistant pancreatic cancer cells (such as Panc…
… in gemcitabine-sensitive but not gemcitabine-resistant pancreatic cancer cells (such as Panc…
Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer
T Arumugam, V Ramachandran, KF Fournier, H Wang… - Cancer research, 2009 - AACR
… Identification of global gene expression patterns of pancreatic cancer cells. Our results
suggested that drug sensitivity and resistance might be controlled by broad-based mechanism(s). …
suggested that drug sensitivity and resistance might be controlled by broad-based mechanism(s). …
Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity
X Shi, Y Li, Q Yuan, S Tang, S Guo, Y Zhang… - Nature …, 2022 - nature.com
… screening reveals a chromatin accessibility signature associated with drug sensitivity To
characterize the drug sensitivity signatures of pancreatic cancer, we performed primary drug …
characterize the drug sensitivity signatures of pancreatic cancer, we performed primary drug …
[HTML][HTML] Drug resistance in pancreatic cancer: Impact of altered energy metabolism
C Grasso, G Jansen, E Giovannetti - Critical reviews in oncology …, 2017 - Elsevier
… drug resistance and discusses possible novel applications of metabolic inhibition for the
development of more effective drugs against pancreatic cancer… therapeutics and drug sensitivity …
development of more effective drugs against pancreatic cancer… therapeutics and drug sensitivity …
Challenges of drug resistance in the management of pancreatic cancer
R Sheikh, N Walsh, M Clynes, R O'Connor… - Expert review of …, 2010 - Taylor & Francis
… sensitivity by reverse transcription PCR (RT-PCR) Citation[21]. Through an examination of
six pancreatic cancer … of drug sensitivity, and the higher the ratio the more sensitive the cell …
six pancreatic cancer … of drug sensitivity, and the higher the ratio the more sensitive the cell …
Pancreatic cancer: understanding and overcoming chemoresistance
Z Wang, Y Li, A Ahmad, S Banerjee, AS Azmi… - Nature reviews …, 2011 - nature.com
… drugs; the cancer cells might initially show drug sensitivity, but … drug resistance in patients
with pancreatic cancer. Consistent with these reports, pancreatic cancer cells that are sensitive …
with pancreatic cancer. Consistent with these reports, pancreatic cancer cells that are sensitive …
CNT1 expression influences proliferation and chemosensitivity in drug-resistant pancreatic cancer cells
YD Bhutia, SW Hung, B Patel, D Lovin, R Govindarajan - Cancer research, 2011 - AACR
… drug-resistant pancreatic cancer. Our data identify novel mechanisms for nucleoside drug
resistance in pancreatic cancer … improving nucleoside drug sensitivity in pancreatic cancer. In …
resistance in pancreatic cancer … improving nucleoside drug sensitivity in pancreatic cancer. In …
Genetically Defined Subsets of Human Pancreatic Cancer Show Unique In Vitro Chemosensitivity
Y Cui, JA Brosnan, AL Blackford, S Sur, RH Hruban… - Clinical cancer …, 2012 - AACR
… In summary, among the sensitive drugs, outlier pancreatic cancer cell lines were more …
between genetic and transcriptomic profiles and drug sensitivities. We found that somatic …
between genetic and transcriptomic profiles and drug sensitivities. We found that somatic …
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