Pharmacogenetics of anticancer drug sensitivity in pancreatic cancer

E Giovannetti, V Mey, S Nannizzi, G Pasqualetti… - Molecular Cancer …, 2006 - AACR
… Due to the delay of clinical diagnosis, pancreatic cancer is often … drugs and has produced
unsatisfactory results. Gemcitabine is now the standard drug for advanced pancreas cancer (4)…

Metformin influences drug sensitivity in pancreatic cancer cells

S Candido, SL Abrams, L Steelman… - Advances in biological …, 2018 - Elsevier
… Metformin, by itself, was not effective at suppressing growth of the pancreatic cancerdrugs
used to treat pancreatic cancer (eg., gemcitabine, cisplatin, 5-fluorouracil) and other cancer

Overcoming drug resistance in pancreatic cancer

J Long, Y Zhang, X Yu, J Yang, DG LeBrun… - Expert opinion on …, 2011 - Taylor & Francis
… gemcitabine killing of gemcitabine-sensitive pancreatic cancer cells such as BxPC-3 cells
… in gemcitabine-sensitive but not gemcitabine-resistant pancreatic cancer cells (such as Panc…

Epithelial to mesenchymal transition contributes to drug resistance in pancreatic cancer

T Arumugam, V Ramachandran, KF Fournier, H Wang… - Cancer research, 2009 - AACR
… Identification of global gene expression patterns of pancreatic cancer cells. Our results
suggested that drug sensitivity and resistance might be controlled by broad-based mechanism(s). …

Integrated profiling of human pancreatic cancer organoids reveals chromatin accessibility features associated with drug sensitivity

X Shi, Y Li, Q Yuan, S Tang, S Guo, Y Zhang… - Nature …, 2022 - nature.com
… screening reveals a chromatin accessibility signature associated with drug sensitivity To
characterize the drug sensitivity signatures of pancreatic cancer, we performed primary drug

[HTML][HTML] Drug resistance in pancreatic cancer: Impact of altered energy metabolism

C Grasso, G Jansen, E Giovannetti - Critical reviews in oncology …, 2017 - Elsevier
drug resistance and discusses possible novel applications of metabolic inhibition for the
development of more effective drugs against pancreatic cancer… therapeutics and drug sensitivity

Challenges of drug resistance in the management of pancreatic cancer

R Sheikh, N Walsh, M Clynes, R O'Connor… - Expert review of …, 2010 - Taylor & Francis
sensitivity by reverse transcription PCR (RT-PCR) Citation[21]. Through an examination of
six pancreatic cancer … of drug sensitivity, and the higher the ratio the more sensitive the cell …

Pancreatic cancer: understanding and overcoming chemoresistance

Z Wang, Y Li, A Ahmad, S Banerjee, AS Azmi… - Nature reviews …, 2011 - nature.com
drugs; the cancer cells might initially show drug sensitivity, but … drug resistance in patients
with pancreatic cancer. Consistent with these reports, pancreatic cancer cells that are sensitive

CNT1 expression influences proliferation and chemosensitivity in drug-resistant pancreatic cancer cells

YD Bhutia, SW Hung, B Patel, D Lovin, R Govindarajan - Cancer research, 2011 - AACR
drug-resistant pancreatic cancer. Our data identify novel mechanisms for nucleoside drug
resistance in pancreatic cancer … improving nucleoside drug sensitivity in pancreatic cancer. In …

Genetically Defined Subsets of Human Pancreatic Cancer Show Unique In Vitro Chemosensitivity

Y Cui, JA Brosnan, AL Blackford, S Sur, RH Hruban… - Clinical cancer …, 2012 - AACR
… In summary, among the sensitive drugs, outlier pancreatic cancer cell lines were more …
between genetic and transcriptomic profiles and drug sensitivities. We found that somatic …