… However, the mechanisms by which paracrine signals regulate … pancreatic cancer cell lines,
Panc-1 and MiaPaCa-2, reacted differently when treated with hepatocyte growth factor (HGF…

… HGF production in the CM of the two human pancreatic cancer lines and PSCs with a human
HGF … HGF production was then assayed in direct and indirect co-cultures of PSCs and …

… HGF level was significantly changed in pancreatic tumor tissues compared to adjacent
normal control tissues (Fig. 1k). Taken together, these results indicate that α-SMA + PSC highly …

… if so, whether and how HGF influences cell invasion, proliferation, … human pancreatic cancer
cell-derived IL-1α enhances HGF … that a paracrine factor secreted by pancreatic cancer cells …

… of the MET/HGF paracrine loop in the metastatic spreading of PDAC tumors [101,102]. The
MET/HGF axis has been proven to further stimulate HGF production by mesenchymal cells, …

… This work first serves to validate this finding in pancreatic cancer. To address the … that
paracrine growth factor signaling within the stroma-rich pancreatic cancer microenvironment may …

… -associated fibroblasts also reprogram the ECM to retain more paracrine HGF, which in
turn positively affects the activation of c-MET and its downstream signaling pathways, thereby …

… is highly expressed in stromal cells (PSCs, RSC96) of PC, but is not expressed in PC cells,
which showed that HGF is a paracrine mediator produced by nonparenchymal and stromal …

… in cancer cell ferroptosis, we speculate PSCs may function in a paracrine avenue to promote
pancreatic cancer … pancreatic cancer cell ferroptosis resistance. Activated PSCs secreted …

… of HIF-1α in cancer and stromal cells exists within pancreatic cancer tissue specimens. We
next examined the immunostaining of HGF/c-Met in pancreatic cancer tissue specimens. The …