… provided strong evidence on the role of PI3K/AKT/mTOR pathway in PDAC, clinical studies
in … PI3K/AKT/mTOR pathway could provide valuable assets for treatment of pancreatic cancer …

… pancreatic cancer patients. In this review, we focus on PI3K/AKT/mTOR inhibitors that have
shown great anti-tumor potential in studies performed on xenograft models and pancreatic …

… that PI3K pathway is constitutively activated in pancreatic cancer cells and PI3K suppression
… cancer cells through negative modulation of the PI3K/Akt/mTOR signaling pathway [47]. …

… of multiple protumorigenic pathways in … PI3K/AKT/mTOR signaling pathway, induced cell-cycle
arrest, and increased apoptosis. Uro A successfully attenuated tumor growth in both tumor …

… (PI3K)/serine-threonine kinase (AKT) signal transduction that can be recognized and bound
by rapamycin [12]. mTOR … effect of mTOR in human pancreatic cancer SW1990 cells and to …

… autophagy by the PI3K/Akt/mTOR signaling pathway in pancreatic cancer. The autophagy …
ROS production of pancreatic cancer. The effect of autophagy in pancreatic cancer is also the …

… The nude mouse xenograft experiment demonstrated the tumor suppressive ability of …
pancreatic cancer cell proliferation and apoptosis by suppressing the PI3K/AKT/mTOR pathway …

… inhibition of PI3K/Akt/mTOR pathway and … pancreatic cancer contains pancreatic CSCs, we
sought to examine the molecular mechanism by which ROT induces autophagy in pancreatic …

… and the PI3K/Akt/mTOR pathway affect pancreatic cancer … pancreatic cancer progression
and the occurrence of spontaneous liver metastasis by modulating the PI3K/Akt/mTOR pathway …

… Carboxypeptidase A4 (CPA4), as a novel tumor biomarker, is prevalently observed in various
cancers. However, the potential role of CPA4 in pancreatic cancer (PC), to our knowledge, …