… that PI3K pathway is constitutively activated in pancreatic cancer cells and PI3K suppression
… Furthermore, Pettazzoni and colleagues have shown that inhibition of the MAPK or PI3K-…

… the proliferation, apoptosis and autophagy of human pancreatic cancer (PC) cell lines in vitro
… to establish an orthotopic pancreatic tumor model in nude mice. Tumor‑bearing nude mice …

… growth and induces apoptosis in pancreatic cancer cells through regulation of FOXO … in
pancreatic cancer cells. Our results demonstrate that inhibition of PI3K/AKT and ERK pathways …

… Our findings indicated that scoparone inhibits pancreatic cancer … arrest and apoptosis through
the PI3K/Akt signaling pathway. … MAPK signaling pathway, the PI3K/Akt signaling pathway, …

… The high frequency of KRAS mutations in pancreatic cancer makes the RAS/MAPK pathway
an attractive target for intervention. The emergence of highly potent and selective small-…

… Pancreatic cancer is generally characterized with high levels of malignancy and poor …
gastric cancer. Therefore, the present study explored the effects of apatinib on pancreatic cancer. …

… of targeting the PI3K-AKT and MAPK pathways in PDAC that … dual targeting of PI3K-AKT
and MAPK pathways can have an … of the PI3K-AKT and MAPK pathways with chemotherapy, …

… via different signaling pathways. We previously reported that the activation of the PI3K
and MAPK pathways could enhance the invasion and metastasis of pancreatic cancer cells [19,20]…

… pathways are known to converge on the MAPK and PI3K … the downstream pathways, such
as the MAPK or PI3K pathways.… response to RTK, MAPK or PI3K pathway inhibition in PDAC. …

… this signalling pathway and in particular Class I PI3K isoforms for pancreatic cancer treatment.
… incriminated downstream of EGFR activation implicate both PI3K and MAPK pathways. …