Targeting the Akt/PI3K signaling pathway as a potential therapeutic strategy for the treatment of pancreatic cancer
… that PI3K pathway is constitutively activated in pancreatic cancer cells and PI3K suppression
… Furthermore, Pettazzoni and colleagues have shown that inhibition of the MAPK or PI3K-…
… Furthermore, Pettazzoni and colleagues have shown that inhibition of the MAPK or PI3K-…
[HTML][HTML] Effects of evodiamine on PI3K/Akt and MAPK/ERK signaling pathways in pancreatic cancer cells
Z Hong, Z Wang, B Zhou, J Wang… - International …, 2020 - spandidos-publications.com
… the proliferation, apoptosis and autophagy of human pancreatic cancer (PC) cell lines in vitro
… to establish an orthotopic pancreatic tumor model in nude mice. Tumor‑bearing nude mice …
… to establish an orthotopic pancreatic tumor model in nude mice. Tumor‑bearing nude mice …
[HTML][HTML] Inhibition of PI3K/AKT and MAPK/ERK pathways causes activation of FOXO transcription factor, leading to cell cycle arrest and apoptosis in pancreatic cancer
SK Roy, RK Srivastava, S Shankar - Journal of molecular signaling, 2010 - Springer
… growth and induces apoptosis in pancreatic cancer cells through regulation of FOXO … in
pancreatic cancer cells. Our results demonstrate that inhibition of PI3K/AKT and ERK pathways …
pancreatic cancer cells. Our results demonstrate that inhibition of PI3K/AKT and ERK pathways …
[HTML][HTML] Scoparone inhibits pancreatic cancer through PI3K/Akt signaling pathway
N Li, F Yang, DY Liu, JT Guo, N Ge… - World journal of …, 2021 - ncbi.nlm.nih.gov
… Our findings indicated that scoparone inhibits pancreatic cancer … arrest and apoptosis through
the PI3K/Akt signaling pathway. … MAPK signaling pathway, the PI3K/Akt signaling pathway, …
the PI3K/Akt signaling pathway. … MAPK signaling pathway, the PI3K/Akt signaling pathway, …
Cotargeting MAPK and PI3K signaling with concurrent radiotherapy as a strategy for the treatment of pancreatic cancer
TM Williams, AR Flecha, P Keller, A Ram… - Molecular cancer …, 2012 - AACR
… The high frequency of KRAS mutations in pancreatic cancer makes the RAS/MAPK pathway
an attractive target for intervention. The emergence of highly potent and selective small-…
an attractive target for intervention. The emergence of highly potent and selective small-…
[HTML][HTML] Apatinib inhibits pancreatic cancer growth, migration and invasion through the PI3K/AKT and ERK1/2/MAPK pathways
Y Hu, J Jing, Y Shi, P Zhang, D Dong… - Translational Cancer …, 2021 - ncbi.nlm.nih.gov
… Pancreatic cancer is generally characterized with high levels of malignancy and poor …
gastric cancer. Therefore, the present study explored the effects of apatinib on pancreatic cancer. …
gastric cancer. Therefore, the present study explored the effects of apatinib on pancreatic cancer. …
Dual inhibition of the PI3K and MAPK pathways enhances nab-paclitaxel/gemcitabine chemotherapy response in preclinical models of pancreatic cancer
… of targeting the PI3K-AKT and MAPK pathways in PDAC that … dual targeting of PI3K-AKT
and MAPK pathways can have an … of the PI3K-AKT and MAPK pathways with chemotherapy, …
and MAPK pathways can have an … of the PI3K-AKT and MAPK pathways with chemotherapy, …
[HTML][HTML] ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways
Y Wu, X Tan, P Liu, Y Yang, Y Huang, X Liu… - Experimental cell …, 2019 - Elsevier
… via different signaling pathways. We previously reported that the activation of the PI3K
and MAPK pathways could enhance the invasion and metastasis of pancreatic cancer cells [19,20]…
and MAPK pathways could enhance the invasion and metastasis of pancreatic cancer cells [19,20]…
Combating pancreatic cancer with PI3K pathway inhibitors in the era of personalised medicine
JRW Conway, D Herrmann, TRJ Evans, JP Morton… - Gut, 2019 - gut.bmj.com
… pathways are known to converge on the MAPK and PI3K … the downstream pathways, such
as the MAPK or PI3K pathways.… response to RTK, MAPK or PI3K pathway inhibition in PDAC. …
as the MAPK or PI3K pathways.… response to RTK, MAPK or PI3K pathway inhibition in PDAC. …
Implication of PI3K/Akt pathway in pancreatic cancer: When PI3K isoforms matter?
R Baer, C Cintas, N Therville… - Advances in biological …, 2015 - Elsevier
… this signalling pathway and in particular Class I PI3K isoforms for pancreatic cancer treatment.
… incriminated downstream of EGFR activation implicate both PI3K and MAPK pathways. …
… incriminated downstream of EGFR activation implicate both PI3K and MAPK pathways. …
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