… , by establishing an immunosuppressive tumor microenvironment. Cytokines secreted by …
improve the unfavorable tumor microenvironment associated with pancreatic cancer. CAR-T…

… cells in fostering pancreatic cancer cell growth and … pancreatic tumor microenvironment
which may permit the development of novel, more effective treatments for pancreatic cancer…

… that this desmoplastic microenvironment of pancreatic cancer — which is forming approximately
eighty percent of the tumor mass — is not a passive scaffold for the tumor cells but an …

… Some molecules participate in both microenvironment formation and … of pancreatic
cancer microenvironment formation and discuss how the pancreatic cancer microenvironment …

… between tumor and immune cells within the tumor microenvironment (TME) play important
roles in the pathogenesis and progression of the disease [20]. On the one hand, the tumor …

… targeting the tumor stroma of pancreatic cancer. The TME of pancreatic cancer is characterized
… Pancreatic stellate cells (PSCs) and cancer associated fibroblasts (CAFs) are the main …

… pancreatic cancer remains one of the most lethal diseases worldwide. Unlike other solid
tumors, pancreatic cancer … , resulting in persistent and severe hypoxia within the tumor. Hypoxic …

… that dictate the fate and function of cancer cells. Herein, we discuss recent … tumor
microenvironment in PDAC and how the microenvironment that surrounds cancer cells shapes tumor …

… be engaged to minimize off-target toxicity in cancer therapy. Furthermore, some biomaterials
could be responsive to the tumor microenvironment (TME) and subsequently exhibit their …

… In PDAC specifically, pancreatic tumor cells produce GM-CSF, which encourages the
accumulation of MDSCs in the tumor microenvironment, thereby limiting T-cell responses. …