… A human pancreas contains ∼1 million pancreatic islets (6). The pancreatic islets consist of
… cells, of which the insulin-secreting β cells (50% of the cells in human islets), the glucagon-…

… insulin action and a loss of the normal insulin secretion response to glucose. Glucose
stimulates insulin secretion … or amplifying phase of this secretory response, have been recently …

… of glucose-induced insulin secretion are of … -insulin dynamics by incorporating the detailed
spatial distribution of the concentrations of interest within isolated avascular pancreatic islets. …

… 1.0% in control islets, respectively (p < 0.01). We conclude that insulin secretion stimulated
by glucose is markedly impaired in GK rat islets. Glucose metabolism is also altered in GK rat …

… Coordinated pulses of electrical activity and insulin secretion are a hallmark of the islet of …
also leads to increased insulin secretion at low glucose levels. Islets without gap junctions …

… Pancreatic islet B cell function was studied in vitro using three … of islet tissues: isolated, intact
islets, dispersed islet cells attached singly to microcarrier beads, and reaggregated islet cells…

… , pancreatic islet-specific miRNA that inhibits insulin secretion at a … of insulin secretion and
many of the miRNAs we identified in MIN6 cells may also have roles in endocrine pancreas …

… to regulate insulin release, we examined the effect of several agonists and antagonists of
insulin secretion. The mechanism by which glucose stimulates insulin secretion in vivo is …

… of hyperinsulinemia and augmented pancreatic islet insulin secretion during pregnancywere
… On day 21, pancreatic islets were isolated by a collagenase method. Total insulin secretion …

… for function and survival of the endocrine pancreas, the islet of Langerhans (1). Activation
of muscarinic receptors leads to improved insulin secretion from pancreatic islets (2–7). …