… (a) A heterozygous missense mutation (T1796A/V599E) was identified in exon 15 in a
papillary carcinoma sample, PTC20 T. (b) Nucleotide sequence in the corresponding normal …

… ) and found the same BRAF mutation in six (67%… exons 11 and 15 in all T1796A-negative
papillary thyroid cancers and in 10 T1796A-positive tumors but did not identify additional BRAF …

… alterations in the thyroid parenchyma surrounding the tumor. To explore the early … BRAF
exon 15 in 30 PTCs and in 100 samples from the thyroid parenchyma surrounding the tumor. …

… Polymerase chain reaction was performed for an amplicon in BRAF exon 15 that includes
the mutation site. Cycle sequencing was performed using the BigDye Terminator kit and …

… mutated in human carcinomas, … BRAF mutation in papillary thyroid carcinoma (PTC) of
Koreans through direct DNA sequencing of the polymerase chain reaction (PCR)amplified exon …

… in the BRAF kinase … BRAF mutations in thyroid cancer and their correlation with
clinicopathological parameters. We analyzed exons 11 and 15 of BRAF gene in six human thyroid …

… within exons 11 and 15 of the BRAF gene by SSCP as previously described (9). For exon
15 … NPA cells (BRAF V599E ); and for exon 11 mutations, we used DNA from the small cell …

… BRAF is also mutated in thyroid tumors and cell lines. We analyzed BRAF gene mutation at
codon 599 in thyroid tumors … A PCR reaction that amplifies BRAF exon 15 was included as a …

… To confirm BRAF mutation in these samples, PCR-amplified exon 15 was directly sequenced
using two primers flanking it. Shown in Figure 1B are two representative DNA sequences of …

… The aim of the study was to describe a large cohort of rare exon 15 BRAF alterations (r-BRAF)
and the clinicopathological features of PTC harboring these alterations and to clarify their …