BRAF mutation in papillary thyroid carcinoma: pathogenic role and clinical implications

KT Tang, CH Lee - Journal of the chinese medical association, 2010 - journals.lww.com
… the most rapidly increasing cancer among women and the … thyroid cancers are classified
into papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), and anaplastic thyroid cancer

BRAF mutation in papillary thyroid carcinoma

Y Cohen, M Xing, E Mambo, Z Guo… - … the National Cancer …, 2003 - academic.oup.com
papillary thyroid tumors (5). Our observation of a high frequency of BRAF-activating mutations
in papillary thyroid carcinoma … the development of human papillary thyroid carcinoma. This …

BRAF Mutation in Papillary Thyroid Cancer: Pathogenic Role, Molecular Bases, and Clinical Implications

M Xing - Endocrine reviews, 2007 - academic.oup.com
… Therefore, activating mutation of the BRAF gene is of particular importance in human cancers,
especially in those that show a high prevalence of this mutation, such as thyroid cancer (13…

Pathology and genetics of thyroid carcinoma

RA DeLellis - Journal of surgical oncology, 2006 - Wiley Online Library
… In papillary thyroid carcinoma (PTC), genetic events involve … and RAS (mutations), although
RAS mutations are uncommon … mutation in papillary thyroid carcinoma and thyroid tumor cell …

Prognostic utility of BRAF mutation in papillary thyroid cancer

M Xing - Molecular and cellular endocrinology, 2010 - Elsevier
… The vast majority of thyroid cancers originate from follicular epithelial cells, which are … as
papillary thyroid cancer (PTC), follicular thyroid cancer (FTC), and anaplastic thyroid cancer (…

[PDF][PDF] BRAF (V600E) mutation and the biology of papillary thyroid cancer

F Frasca, C Nucera, G Pellegriti, P Gangemi… - … -related cancer, 2008 - academia.edu
BRAF (V600E) mutation is the most frequent genetic alteration in papillary thyroid carcinomas
(PTCs) that are 80–90% of all thyroid cancers. We evaluated the relationship between …

Papillary thyroid carcinoma: an overview

N Al-Brahim, SL Asa - Archives of pathology & laboratory …, 2006 - meridian.allenpress.com
… gene mutation rather than a germline mutation in one example of this … in papillary thyroid
carcinoma (original magnification 200). b, The cytokeratin 19 stains papillary thyroid carcinoma

Optimizing surgical treatment of papillary thyroid carcinoma associated with BRAF mutation

L Yip, MN Nikiforova, SE Carty, JH Yim, MT Stang… - Surgery, 2009 - Elsevier
… , a mutation of the BRAF oncogene is the most common genetic alteration found in papillary
thyroid carcinoma (… extension, lymph node metastasis, and tumor recurrence. It is not known …

BRAF mutations are associated with some histological types of papillary thyroid carcinoma

V Trovisco, I Vieira de Castro, P Soares… - The Journal of …, 2004 - Wiley Online Library
Mutations in the BRAF gene have recently been detected in a wide range of neoplastic …
in melanoma and papillary thyroid carcinoma (PTC). The hot-spot mutation BRAF V599E is …

BRAFV600E Mutation and Outcome of Patients with Papillary Thyroid Carcinoma: A 15-Year Median Follow-Up Study

R Elisei, C Ugolini, D Viola, C Lupi… - The Journal of …, 2008 - academic.oup.com
… Survival curves of PTC patients with and without the BRAF V600E mutation. Patients with
thyroid tumors harboring the BRAF V600E mutation showed a significantly lower survival rate (…