The need for paradigm shift: prognostic significance and implications of standard therapy-related systemic immunosuppression in glioblastoma for immunotherapy …

AA Stepanenko, AO Sosnovtseva, MP Valikhov… - Frontiers in …, 2024 - frontiersin.org
… local immunosuppression in glioblastoma and its prognostic significance), we focused on …
immunosuppression at baseline and the prognostic significance of different circulating and …

Albert C. Broders' paradigm shifts involving the prognostication and definition of cancer

JR Wright Jr - Archives of pathology & laboratory medicine, 2012 - meridian.allenpress.com
… that histopathologic findings could independently predict prognosis. This discovery quickly
begat … Historians recognize that science progresses through a series of paradigm shifts. Most …

[HTML][HTML] Paradigm shifts of heart failure therapy: do we need another paradigm?

HY Lee, BH Oh - International Journal of Heart Failure, 2020 - ncbi.nlm.nih.gov
Prognostic significance of left axis deviation in acute heart failure patients with left bundle
branch block: an analysis from the Korean Acute Heart Failure (KorAHF) registry …

Predictive biomarkers: a paradigm shift towards personalized cancer medicine

NB La Thangue, DJ Kerr - Nature reviews Clinical oncology, 2011 - nature.com
… biomarkers; prognostic, pharmacodynamic and predictive. A prognostic biomarker anticipates
… More recent versions of prognostic biomarkers include the Oncotype DX ® test (Genomic …

[HTML][HTML] On fibrosis, prognosis, and the unique role of CMR: a paradigm shift from “bright is dead” to “bright is bad”

C Bucciarelli-Ducci, CF Azevedo - Journal of the American College of …, 2014 - jacc.org
… (14) report the prognostic significance of LGE in 154 patients undergoing AVR for severe AS
(aortic … Prognostic significance of LGE by CMR in aortic stenosis patients undergoing valve …

Two colons‐two cancers: paradigm shift and clinical implications

P Gervaz, P Bucher, P Morel - Journal of surgical oncology, 2004 - Wiley Online Library
… Thus, a new paradigm has emerged with the discovery that CC is a heterogeneous disease;
… originating from the proximal colon have a better prognosis due to a high percentage of MSI-…

Paradigm shift of staging and treatment for early breast cancer in the sentinel lymph node era

SPL Leong - The Breast Journal, 2006 - Wiley Online Library
Lymph node status is the most reliable prognostic indicator for the clinical outcome of
patients with most solid cancers. Because it is the first node draining the primary cancer, the …

The next paradigm shift in the management of clear cell renal cancer: Radiogenomics—Definition, current advances, and future directions

N Gopal, P Yazdian Anari, E Turkbey, EC Jones… - Cancers, 2022 - mdpi.com
… that represent distinct genotypes with prognostic significance, radiogenomics can improve
… As with current biomarkers, these imaging phenotypes should have prognostic significance; …

Treatment paradigm shift may improve survival of patients with high risk superficial bladder cancer

GV Raj, H Herr, AM Serio, SM Donat, BH Bochner… - The Journal of …, 2007 - Elsevier
… Recently a paradigm shift has occurred since patients are … In this study we explored the effect
of this paradigm shift on … we examined the effect of the paradigm shift toward earlier RC in a …

From diagnosis to prognosis: A paradigm shift for multimodal imaging in assessing diabetic macular edema

A Apuzzo, S Gravina, G Panozzo… - European Journal …, 2024 - journals.sagepub.com
… Multimodal imaging (MMI) has allowed a shift from DME diagnosis to prognosis. Although …
predict treatment response and long-term visual prognosis. The purpose of this editorial is to …