The paradox of autophagy and its implication in cancer etiology and therapy

A Eisenberg-Lerner, A Kimchi - Apoptosis, 2009 - Springer
autophagy and cancer is complex. This review will discuss the link … autophagy and
cancer and will explore different autophagy-inducing drugs that are being used as anti-cancer

Crosstalk between ROS and autophagy in tumorigenesis: understanding the multifaceted paradox

A Hasan, SF Rizvi, S Parveen, N Pathak, A Nazir… - Frontiers in …, 2022 - frontiersin.org
… Moreover, autophagy also plays a dual role, initially inhibiting tumor formation but … autophagy
and ROS where they can either suppress cancer formation or promote disease etiology. …

Dual role of autophagy in hallmarks of cancer

SS Singh, S Vats, AYQ Chia, TZ Tan, S Deng, MS Ong… - Oncogene, 2018 - nature.com
autophagy, mechanism of autophagy, as well as the paradoxical role of autophagy in cancer.
… elaborate on how autophagy plays a role in several hallmarks of cancer, and emergence of …

Telomeres and cancer: resolving the paradox

J Nassour, TT Schmidt… - Annual review of cancer …, 2021 - annualreviews.org
… This review focuses on the current knowledge of the dual role of telomeres in cancer and …
etiology. … It is worthy to note, however, that the role of autophagy in cancer is dynamic and …

The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death

RA González-Polo, P Boya, AL Pauleau… - Journal of cell …, 2005 - journals.biologists.com
… and the massive accumulation of autophagic vacuoles in various tissues (Eskelinen et al.,
2002; Tanaka et al., 2000). Loss of LAMP2 is also at the etiology of Danon disease, an X-…

Autophagy: cancer's friend or foe?

SK Bhutia, S Mukhopadhyay, N Sinha, DN Das… - Advances in cancer …, 2013 - Elsevier
autophagy as a homeostatic and regulatory mechanism is underscored by the association
of autophagy defects in the etiology … -promoting drugs may involve unwanted paradoxical

The roles, controversies, and combination therapies of autophagy in lung cancer

Z Wang, C Zhou, S Yang - Cell Biology International, 2022 - Wiley Online Library
… exact function of autophagy in lung cancer are contradictory, … on lung cancer is that targeting
autophagy combined with … paradoxical reports about the exact function of autophagy in …

Molecular pathways: autophagy in cancer—a matter of timing and context

M Cicchini, V Karantza, B Xia - Clinical cancer research, 2015 - AACR
… in the etiology and/or … autophagy in cancer is complex and varies depending on the timing
and context of tumor development. Yet, despite the seemingly paradoxical roles of autophagy

The multifaceted roles of autophagy in tumors—implications for breast cancer

J Debnath - Journal of mammary gland biology and neoplasia, 2011 - Springer
… and suppressive functions for autophagy, these paradoxical effects are reconciled through
a model in which the exact role of autophagy during cancer progression depends on tumor …

Therapeutic modulation of autophagy: which disease comes first?

MC Maiuri, G Kroemer - Cell Death & Differentiation, 2019 - nature.com
… On a pessimistic note, it is possible that close-to-etiological treatments like autophagy
induction would be administered at a stage that is too late to arrest—let alone, to revert—the …