… assembled in the cytoplasm of innate immune cells in response to microbial molecules or
stress signals. Upon assembly, the inflammasomes … for restricting parasite replication and for …

… NLRP3 inflammasome assembly cleaves its different inactive substrates [pro-interleukin (IL)-1β,
pro-IL-18, Gasdermin-D (GSDMD)] in their active forms, promoting inflammation and cell …

… amazonensis replication in macrophages and in vivo. To address this question, we measured
parasite replication in BMDMs obtained from C57BL/6, Casp1/11 −/− , and Clec7a −/− …

… production dependent of the inflammasome assembly, which in its … and, ultimately, lead to
restriction of parasite replication. … induce inflammasome activation and to control the parasite …

… Here we found that inflammasome activation in response to … and leads to restriction of parasite
replication in macrophages. … (i) assembly of the NLRP3 inflammasome (as demonstrated …

… inflammasome. Viral core protein directs intracellular calcium mobilization to impart NLRP3
inflammasome assembly … also plays an important role in limiting EV-A71 replication in …

… plays an important role in limiting parasite replication to promote murine survival. Our …
induces, activation leads to the assembly of the inflammasome, a multiprotein complex that recruits …

… and lead to caspase-11–mediated inflammasome activation in macrophages (38). Similarly,
damage associated with parasite replication might lead to indirect NLRP6 activity within …

… by multiple proteins that assemble in cell cytoplasm after DAMPs … inflammasome engagement,
13 , 26 therefore, we asked whether this inflammasome would be required for the parasite …

… assembly of the NLRP3 inflammasome (assessed by ASC specks), Caspase-1 activation
(assessed by FAM-YVAD) and restriction of parasite replication via the NLRP3 inflammasome […