The history of Parkinson's disease: early clinical descriptions and neurological therapies

CG Goetz - Cold Spring Harbor perspectives in …, 2011 - perspectivesinmedicine.cshlp.org
… vibratory therapy for the management of Parkinson's disease. Charcot had observed that
after long carriage, train, or horseback rides, patients with Parkinson's disease experienced …

A stage-based approach to therapy in Parkinson's disease

C Carrarini, M Russo, F Dono, M Di Pietro, MG Rispoli… - Biomolecules, 2019 - mdpi.com
… In a small cohort of patients with idiopathic RBD (iRBD), the presence of smell impairment
has been detected as a predictive value for conversion to PD and to Parkinson disease with …

Functional models of Parkinson's disease: a valuable tool in the development of novel therapies

P Jenner - Annals of Neurology: Official Journal of the …, 2008 - Wiley Online Library
therapy in the form of l-dopa and dopamine agonist drugs is … treatments for other
neurodegenerative diseases. But 40 … dopaminergic therapy and the problems that drug treatment …

Parkinson's disease: diagnosis and treatment

SS Rao, LA Hofmann, A Shakil - American family physician, 2006 - aafp.org
… Depression Initiate counseling; consider drug therapy with selective serotonin reuptake
inhibitors or tricyclic antidepressants (because of side effect profile, use tricyclic antidepressants …

Milestones in Parkinson's disease therapeutics

O Rascol, A Lozano, M Stern, W Poewe - Movement disorders, 2011 - Wiley Online Library
… of drug therapy. STN DBS was first reported to have a major impact on the symptoms of
PD by Benabid and his colleagues114, 115 and in the last decade, numerous studies have …

Rationale for current therapies in Parkinson's disease

J Romrell, HH Fernandez, MS Okun - Expert opinion on …, 2003 - Taylor & Francis
… of dopaminergic drugs can be escalated to treat Parkinsonian … dopaminergic therapy and
therefore worsened Parkinsonian … in patients with early Parkinson's disease who were treated …

Parkinson's disease management strategies

A Rajput, AH Rajput - Expert review of neurotherapeutics, 2006 - Taylor & Francis
… LD remains the gold standard of drug therapy, but the question of when to introduce it in
our 62-year-old patient remains. There are two major conflicting considerations. The patient …

Disease‐modifying strategies for Parkinson's disease

LV Kalia, SK Kalia, AE Lang - Movement Disorders, 2015 - Wiley Online Library
… Here we review clinical trials of disease-modifying therapies in PD that were published
since 2013 as well as ongoing clinical trials. We also discuss promising approaches and …

Adjunctive therapies in Parkinson's disease: how to choose the best treatment strategy approach

M Fabbri, MM Rosa, JJ Ferreira - Drugs & Aging, 2018 - Springer
… symptoms by patients with Parkinson’s disease (PD). Treatment … therapies are currently
available for the treatment of end-of-dose motor fluctuations. Additionally, device-aided therapies

Evaluating drug treatments for Parkinson's disease: how good are the trials?

K Wheatley, RL Stowe, CE Clarke, RK Hills… - Bmj, 2002 - bmj.com
Parkinson's disease will increase as the population ages, making it important to identify
reliably the most effective drug therapy … Trials of adjuvant therapy in later Parkinson's disease