… to modify disease progression by ameliorating the underlying pathology. Cellular proteostasis
(protein … Proteostasis is ensured by mechanisms including regulation of protein translation, …

… diseases, including Alzheimer’s disease and amyotrophic lateral sclerosis, we will discuss
PD-specific pathological mechanisms of mitochondrial quality control and proteostasis. …

… In this review, we investigate the relationships between exercise, mitochondrial proteostasis,
and PD and explore the role and mechanisms of mitochondrial proteostasis in delaying PD …

… Chaperones present in the nucleus, mitochondria, and cytosol involved in proteostasis are
Heat shock protein 40 (HSP 40), HSP 70, HSP 90, HSP 100, and small HSPs (sHSPs), Heat …

… is majorly characterized by loss of proteostasis that eventually results in accumulation of …
to the disease and the chaperones and associated co-chaperones involved in the proteostasis …

… may be critical to understanding the disease mechanisms of PD. Proteostasis is essential in
… In this review article, we will highlight recent progress regarding α-Synuclein proteostasis in …

… , mitochondria facilitate cytosolic proteostasis. Increasing evidence suggests that enhancing
mitochondrial proteostasis … , and NDs such as Parkinson's disease (PD), amyotrophic lateral …

… accumulate in mitochondria To trace the connection between mitochondrial proteostasis
and organismal health, we first review the types of damage to the mitochondrial proteome and …

… the evidence that links dysfunction in the proteostasis of certain proteins to the pathology of
… of Parkinson’s disease may be amenable to therapeutic strategies aimed at proteostasis of α-…

… Two proteins that have been associated with familial Parkinson's disease, PTEN-induced
mitochondrial kinase Pink1 and the E3 ubiquitin ligase Parkin, are required for the selective …