Significant roles of neuroinflammation in Parkinson's disease: therapeutic targets for PD prevention

Y Lee, S Lee, SC Chang, J Lee - Archives of pharmacal research, 2019 - Springer
Glial cells outnumber neurons in the brain and play important roles in the neuroinflammation
that accompanies brain damage in neurodegenerative diseases. In Parkinson’s disease (…

Nrf2/ARE pathway as a therapeutic target for the treatment of Parkinson diseases

AP Gureev, VN Popov - Neurochemical Research, 2019 - Springer
Instead of the progress in the understanding of etiology of Parkinson’s disease (PD), effective
methods to prevent the progression of the disease have not been developed and only …

Chaperone-mediated autophagy as a therapeutic target for Parkinson disease

P Campbell, H Morris, A Schapira - … opinion on therapeutic targets, 2018 - Taylor & Francis
Introduction: Parkinson disease (PD) is the most common neurodegenerative movement
disorder. Currently only symptomatic treatments exist for PD, and so the search for potential …

Neuroinflammatory responses and Parkinson'disease: pathogenic mechanisms and therapeutic targets

L Yang, K Mao, H Yu, J Chen - Journal of Neuroimmune Pharmacology, 2020 - Springer
… More importantly, this review also emphasizes the potentially new therapeutic targets of … ,
the inflammasome is emerging as a potential therapeutic target. The level of NLRP3 has been …

[HTML][HTML] Neuroinflammation in Parkinson's disease and its potential as therapeutic target

Q Wang, Y Liu, J Zhou - Translational neurodegeneration, 2015 - Springer
targets for PD and even other neurodegenerative diseases. A … and help to establish effective
therapeutic strategies. In this review, … therapeutic interventions targeting neuroinflammation. …

LAMP2A as a therapeutic target in Parkinson disease

M Xilouri, OR Brekk, D Kirik, L Stefanis - Autophagy, 2013 - Taylor & Francis
Abnormal aggregation of SNCA/α-synuclein plays a crucial role in Parkinson disease (PD) …
, CMA, represents a viable therapeutic target for PD and other synucleinopathies where …

PPAR: a therapeutic target in Parkinson's disease

RK Chaturvedi, MF Beal - Journal of neurochemistry, 2008 - Wiley Online Library
Parkinson’s disease (PD) is a progressive and chronic neurodegenerative disorder,
characterized by progressive loss of dopaminergic neurons in substantia nigra. The etiology and …

TFEB: Pathogenic role and therapeutic target in Parkinson disease

M Decressac, A Björklund - Autophagy, 2013 - Taylor & Francis
Parkinson disease (PD) is characterized by the progressive loss of nigral dopamine
neurons and the presence of accumulations containing the disease-causing protein SNCA/α-…

[HTML][HTML] Mitochondria: a therapeutic target for Parkinson's disease?

Y Luo, A Hoffer, B Hoffer, X Qi - International journal of molecular sciences, 2015 - mdpi.com
Parkinson’s disease (PD) is one of the most common neurodegenerative disorders. The …
We also summarize mitochondria-targeting therapeutics in models of PD, proposing that …

Potential therapeutic targets for Parkinson's disease

J Stoessl - Expert opinion on therapeutic targets, 2008 - Taylor & Francis
Background: Parkinson's disease is a common disorder that becomes more prevalent with
advanced age. The cardinal features are related to dopamine deficiency, arising from loss of …