… have been identified, including defects in the synthesis of ceramides, sphingomyelins and
… , implying partially distinct metabolic pathways, the pathways of SL synthesis in humans are …

… a defect in endogenous ceramide synthesis In order to verify whether ceramide synthesis
in response to exogenous C 6 -ceramide is … , Jurkat and Molt-4 cells with 20 μM C 6 -ceramide. …

… and were reproduced when alternative inhibitors of de novo ceramide synthesis such as
L-cycloserine (which also inhibits SPT) and Fenretinide (dihydroceramide synthase inhibitor) …

… However, the failing myocardium develops a defect in use of both fatty acids and glucose …
, changes protein levels of key enzymes of ceramides synthesis pathways, and partially …

… are mainly composed of ceramides, cholesterol and free fatty acids. Ceramides, and more …
the enzyme PNPLA1 is essential for the last step of synthesis of omega-O-acylceramides. Skin …

… In this study, we directly examined whether ceramide-mediated events are … ceramide
synthesis is activated early following UVB irradiation, an effect attributable to increased ceramide …

… ceramides recycle into long chain ceramides via this pathway [38]). The de novo ceramide
synthetic … ionizing radiation and usually results in a prolonged ceramide elevation [39], [40]. …

… We argue that the main reason for this difference is the partial loss of MECR function in …
an obvious defect in complex assembly in human fibroblasts, possibly because of the partial …

… ACDase defects, accumulated ceramide, … cDNA partially corrected the disease manifestations.
Importantly, we propose in this study a new mechanism that links the build‐up of ceramide …

… (i) a hydrophobic backbone called ceramide, which consists of a sphingosine base with an
amide-linked fatty acid; and (ii) a polar head group. The ceramide, itself, is synthesized in the …