[HTML][HTML] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases
… heritability are currently unknown. We applied variance-component methods to imputed
genotype data for 11 common diseases to partition the heritability … approach partitions heritability …
genotype data for 11 common diseases to partition the heritability … approach partitions heritability …
Partitioning heritability by functional annotation using genome-wide association summary statistics
… Previous work on partitioning SNP heritability has used … Here we introduce a method for
partitioning heritability, stratified … that are not cell type specific and find heritability enrichment in …
partitioning heritability, stratified … that are not cell type specific and find heritability enrichment in …
Partitioned glioma heritability shows subtype-specific enrichment in immune cells
… of LD to estimate heritability and correlations … , cell-type-specific transcriptomic networks)
to heritability in GWAS. In this analysis, we used LDSC to partition glioma heritability by cell type …
to heritability in GWAS. In this analysis, we used LDSC to partition glioma heritability by cell type …
[HTML][HTML] Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait
… , and lymphoblastoid cell lines. The narrow-sense heritability explained by all interrogated
SNPs in each of these data sets was substantially greater than the heritability accounted for …
SNPs in each of these data sets was substantially greater than the heritability accounted for …
Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types
… partitioning heritability from GWAS summary statistics, to sets of specifically expressed genes
to identify disease-relevant tissues and cell types … brain cell types and immune cell types for …
to identify disease-relevant tissues and cell types … brain cell types and immune cell types for …
[HTML][HTML] Topologically associating domain boundaries that are stable across diverse cell types are evolutionarily constrained and enriched for heritability
E McArthur, JA Capra - The American Journal of Human Genetics, 2021 - cell.com
… complex-trait heritability and evolutionary sequence conservation partitioned between TADs
… trait heritability or sequence conservation than TAD boundaries unique to specific tissues? …
… trait heritability or sequence conservation than TAD boundaries unique to specific tissues? …
Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia
… We also confirmed that partitioned heritability estimates for ICV and superior frontal cortex
… Regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet …
… Regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet …
[HTML][HTML] Partitioning gene-mediated disease heritability without eQTLs
… cell type). If multiple gene-associated variables can potentially affect a trait (for example, its
expression levels in different cell types… sufficient to partition mediated heritability across genes…
expression levels in different cell types… sufficient to partition mediated heritability across genes…
[HTML][HTML] Evaluation of heritability partitioning approaches in livestock populations
C Yuan, JL Gualdrón Duarte, H Takeda, M Georges… - BMC genomics, 2024 - Springer
… We herein evaluated the accuracy of GREML and BayesRR-RC in partitioning heritability
according to functional classes, defined mainly on the basis of their position relative to genes …
according to functional classes, defined mainly on the basis of their position relative to genes …
Annotations capturing cell type-specific TF binding explain a large fraction of disease heritability
… across a broad set of diseases and corresponding cell types; this strategy of constructing …
predictions are generally not cell type-specific. We partitioned the heritability of 49 diseases …
predictions are generally not cell type-specific. We partitioned the heritability of 49 diseases …
相关搜索
- cell types heritability enrichment
- cell type disease heritability
- cell type dependency
- association summary statistics partitioning heritability
- diverse cell types
- cell type sequence and chromatin determinants
- functional annotation partitioning heritability
- cell types specifically expressed genes
- cell types domain boundaries
- cell type specific transcription factor
- cell type large fraction
- common diseases partitioning heritability
- common diseases cell type