[HTML][HTML] Partitioning heritability of regulatory and cell-type-specific variants across 11 common diseases

A Gusev, SH Lee, G Trynka, H Finucane… - The American Journal of …, 2014 - cell.com
heritability are currently unknown. We applied variance-component methods to imputed
genotype data for 11 common diseases to partition the heritability … approach partitions heritability

Partitioning heritability by functional annotation using genome-wide association summary statistics

HK Finucane, B Bulik-Sullivan, A Gusev, G Trynka… - Nature …, 2015 - nature.com
… Previous work on partitioning SNP heritability has used … Here we introduce a method for
partitioning heritability, stratified … that are not cell type specific and find heritability enrichment in …

Partitioned glioma heritability shows subtype-specific enrichment in immune cells

QT Ostrom, J Edelson, J Byun, Y Han… - Neuro …, 2021 - academic.oup.com
… of LD to estimate heritability and correlations … , cell-type-specific transcriptomic networks)
to heritability in GWAS. In this analysis, we used LDSC to partition glioma heritability by cell type

[HTML][HTML] Cross-tissue and tissue-specific eQTLs: partitioning the heritability of a complex trait

JM Torres, ER Gamazon, EJ Parra, JE Below… - The American Journal of …, 2014 - cell.com
… , and lymphoblastoid cell lines. The narrow-sense heritability explained by all interrogated
SNPs in each of these data sets was substantially greater than the heritability accounted for …

Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types

HK Finucane, YA Reshef, V Anttila, K Slowikowski… - Nature …, 2018 - nature.com
partitioning heritability from GWAS summary statistics, to sets of specifically expressed genes
to identify disease-relevant tissues and cell types … brain cell types and immune cell types for …

[HTML][HTML] Topologically associating domain boundaries that are stable across diverse cell types are evolutionarily constrained and enriched for heritability

E McArthur, JA Capra - The American Journal of Human Genetics, 2021 - cell.com
… complex-trait heritability and evolutionary sequence conservation partitioned between TADs
… trait heritability or sequence conservation than TAD boundaries unique to specific tissues? …

Partitioning heritability analysis reveals a shared genetic basis of brain anatomy and schizophrenia

PH Lee, JT Baker, AJ Holmes, N Jahanshad, T Ge… - Molecular …, 2016 - nature.com
… We also confirmed that partitioned heritability estimates for ICV and superior frontal cortex
… Regulatory and cell-type-specific variants across 11 common diseases. Am J Hum Genet …

[HTML][HTML] Partitioning gene-mediated disease heritability without eQTLs

DJ Weiner, S Gazal, EB Robinson… - The American Journal of …, 2022 - cell.com
cell type). If multiple gene-associated variables can potentially affect a trait (for example, its
expression levels in different cell types… sufficient to partition mediated heritability across genes…

[HTML][HTML] Evaluation of heritability partitioning approaches in livestock populations

C Yuan, JL Gualdrón Duarte, H Takeda, M Georges… - BMC genomics, 2024 - Springer
… We herein evaluated the accuracy of GREML and BayesRR-RC in partitioning heritability
according to functional classes, defined mainly on the basis of their position relative to genes …

Annotations capturing cell type-specific TF binding explain a large fraction of disease heritability

B van de Geijn, H Finucane, S Gazal… - Human molecular …, 2020 - academic.oup.com
… across a broad set of diseases and corresponding cell types; this strategy of constructing …
predictions are generally not cell type-specific. We partitioned the heritability of 49 diseases …