Approved antiviral drugs over the past 50 years

E De Clercq, G Li - Clinical microbiology reviews, 2016 - Am Soc Microbiol
… groups have been formally approved for the treatment of the following 9 human … antiviral
drugs approved over the past 50 years, shedding light on the development of effective antiviral

Looking back in 2009 at the dawning of antiviral therapy now 50 years ago: an historical perspective

E De Clercq - Advances in Virus Research, 2009 - Elsevier
… -molecular-weight antiviral drug to be licensed for clinical use, was reported by Prusoff (1959).
Now 50 years after this report appeared, we have about 50 antiviral compounds available …

Antivirals: past, present and future

E De Clercq - Biochemical pharmacology, 2013 - Elsevier
… IDU was actually synthesized as a potential antitumor agent, but later became commercialized
as the first antiviral drug to be used in the topical treatment of herpetic eye infections. IDU …

[HTML][HTML] History and progress of antiviral drugs: from acyclovir to direct-acting antiviral agents (DAAs) for Hepatitis C

OL Bryan-Marrugo, J Ramos-Jiménez… - Medicina …, 2015 - Elsevier
… The development of antiviral drugs is a very complex process. Currently, around 50 drugs
… likely that the development of antiviral drugs over the next 20 years will be focused on HIV …

Fifty years in search of selective antiviral drugs: miniperspective

E De Clercq - Journal of medicinal chemistry, 2019 - ACS Publications
… now spanning 50 years in search of selective antiviral agents, I … After I had started to work in
the laboratory (Rega Institute for … application beyond the antiviral area that is in the treatment

Antiviral therapy: old and current issues

G Antonelli, O Turriziani - International journal of antimicrobial agents, 2012 - Elsevier
… During the past 50 years a number of antiviral drugs have … , during the last decade the choice
of antiretroviral drugs has … in prescription patterns, whilst antiviral success has dramatically …

outlook of the antiviral drug Era, now More than 50 years after description of the first antiviral drug

E De Clercq - Antiviral Drug Strategies, 2011 - Wiley Online Library
… some 50 antivirals that have been formally approved, now exactly 50 years after the first
antiviral drug (IDU) was synthesized, the number of potential antiviral drug candidates is steadily …

Another ten stories in antiviral drug discovery (part C):“old” and “new” antivirals, strategies, and perspectives

E De Clercq - Medicinal research reviews, 2009 - Wiley Online Library
… ’’ antiviral drug to be used for treatment of hemorrhagic virus infections? For the treatment of
… Now, almost 50 years after they were first described, IDU and TFT are still used [primarily as …

[HTML][HTML] An Odyssey in antiviral drug development—50 years at the Rega Institute: 1964–2014

E De Clercq - Acta Pharmaceutica Sinica. B, 2015 - ncbi.nlm.nih.gov
… That my stay at the Rega would finally last for 50 years could hardly be anticipated, at the
beginning of an uneventful start of what later could be considered as an equally uneventful …

Highlights in the discovery of antiviral drugs: a personal retrospective

E De Clercq - Journal of medicinal chemistry, 2010 - ACS Publications
antiviral drug to be licensed for clinical use. This marked the birthday of the antiviral drug era,
which has now grown to about 50 … Within 1−2 years after acyclovir, we described BVDU as …