… caspase-1 activation (27, 28, 30). On the basis of our current findings, we propose that pathogen
blockade of TAK1-IKK triggers a caspase-8… Our observations suggest that the blockade …

… Blockade of RIP3 kinase activity with GSK’872 strongly reduced … pathogens, via their T3SS,
can interact with several aspects of host innate immunity via RIP kinases and caspase-8. The …

… RIPK1 in Yersinia-induced death and caspase-1 activation and suggest that this cell death
functions as a host defense against pathogen blockade of inflammatory signaling pathways. …

… Host cells recognize blockade of caspase-8-mediated apoptosis by bacterial pathogens,
and trigger necroptosis as a backup defence strategy. Shigella flexneri counteracts this by type-…

… Successful pathogens have therefore evolved ways to evade host … pathogen-associated
molecular patterns that cannot be recognized by macrophage TLRs or via active blockade of …

… (C) The BMDCs obtained from WT or Casp1/11−/− mice were primed with Pam3CSK4
and under caspase-8 activity blockade were incubated for 24 hours with P brasiliensis at a …

… as a safeguard to pathogenic inhibition of caspase-8. Overall, increasing amounts of
evidence point to caspase-8 as a molecule able to direct cells toward different types of death. …

… of DCs stimulated as in a, with or without blockade of internalization as in a (f,g) or as in c
(h) or in the presence or absence of an inhibitor of caspase-1 or caspase-8 (g). *P < 0.05 and **…

… death requires caspase8 and the apoptotic effectors BAX/BAK Our cell death and immunoblot
data suggested that TNF- and FASL-mediated activation of caspases should contribute to …

… of caspase-8 to cytokine production in response to bacterial infection and individual pathogen-…
As RIPK3-deficient cells do not undergo cell death in response to blockade of caspase …