… caspase-1–deficient primary dendritic cells. Interestingly, we found that caspase-1 was
inhibitory for the activation of caspase-8 in … and bred in our specific pathogen-free animal facility. …

… Blockade of TAK1 kinase activity with the specific inhibitor 5z-7-oxozeaenol (5z7) mimics
the effect of YopJ and pathogenic Yersinia infection to cause RIPK1–caspase-8–dependent …

… pathogenic Yersinia, activates RIPK1 and caspase-8–dependent cell death that promotes
antibacterial defense. While recent studies demonstrate that caspase-8 … pathogen blockade of …

… RIPK3 can also complex with RIPK1, FADD, and caspase-8, which induces caspase-8 …
pathogen sensor for the induction and processing of IL-1beta via a noncanonical caspase-8 …

… Here, we report that caspase-8 is a central mediator of … deficiencies of caspases-8/1/11 or
caspase-8/gasdermin-D (… , but independent role of caspase-8 and caspases-1/11/GSDM-D in …

… discussed as a possible pathogenic mechanism driving Crohn’s … Here we demonstrate a
critical role for caspase-8 in … ) and could be inhibited on blockade of necroptosis. Lastly, we …

… by harmful agents such as pathogens or environmental irritants, … regulated responses against
pathogen-associated molecular … poorly to IL-1 blockade suggesting that targeting upstream …

… During pathogenic infections in vivo, macrophages may encounter both TNF and TLR …
We speculated that TNF blockade might decrease protection from infection by preventing TNF-…

… To determine whether Q-VD-OPH represents a non-antibiotic, host-mediated immunotherapeutic
against other skin pathogens, we evaluated its efficacy against S. pyogenes and P. …

… extracellular pathogens that … Caspase-8 has been identified as an initiator caspase activated
in death receptor-mediated apoptosis [47]. Therefore, we investigated whether blockade …