… To determine whether Q-VD-OPH represents a non-antibiotic, host-mediated immunotherapeutic
against other skin pathogens, we evaluated its efficacy against S. pyogenes and P. …

… extracellular pathogens that … Caspase-8 has been identified as an initiator caspase activated
in death receptor-mediated apoptosis [47]. Therefore, we investigated whether blockade …

… 14, 20), we investigated the role that caspase-8 plays in DC development and in maintaining
tolerance. … Interestingly, specific blockade of caspase-8 activity did not mimic the deletion of …

… components or the downstream cell death executioner gasdermin D (GSDMD) led to an
initial reduction in cell death followed by a robust increase in the incidence of caspase-8– and …

… TLRs are a group of transmembrane receptors first identified in immune cells, which recognize
molecular motifs of pathogen origin and activate immune response. Several reports have …

… caspase-8 impaired the blockade of necroptosis during embryo development. Furthermore,
caspase-8-mediated apoptosis in association with caspase-… in a specific pathogen-free (SPF) …

… This inflammasome is also critical for activation of the inflammatory cysteine protease
caspase-1 in macrophages infected with enteric pathogens, such as Vibrio cholerae, Escherichia …

… caspase-8 in restricting inflammasome-meditated IL-1β overproduction, thereby functioning
as a negative checkpoint against excessive pathogenic … and suppressed by blockade of IL-1β…

… RIPK1 blockade reduced transcription of TNF-α in caspase-8… Similarly to transcription,
blockade of RIPK1 reduced … deletion, the response to these microbial pathogen-associated …

… À/À Mlkl À/À mice did not alter their phenotype, our genetic models formally show that
caspase8 has a FADD-independent role in regulating inflammation in a setting where it is unable …