… Ripk1 or Caspase-1. Our results suggest an in vivo role of the inflammatory RIPK1-caspase-8-…
-independent inflammatory role of caspase-8 that involves activation of an inflammasome. …

… We show that caspase-8 is needed for intestinal pathogen control, as caspase-8 deficient
mice failed to … Thus, our observations reveal a crucial cooperativity between caspase-8 and …

… Knowledge of the underlying mechanisms of the parasite-imposed inhibition will thus
further increase our understanding on the elaborate strategies of this pathogen to evade host …

… Taken together, these data implicate caspase-8 in CD11c-expressing cells in the
maintenance of pathogenic Ly6C lo monocytes and anti-inflammatory synovial tissue-resident …

… caspase-8 is essential for hepatocyte killing in both settings. Loss of Bid, the proapoptotic
BH3-only protein activated by caspase-8 … blockade of this enzyme. Similar to Fas-activation ( …

… [26] and that the FADD-RIPK1-caspase 8 complex is recruited after infection to cleavage …
To our knowledge, the patient P5 here described is the first one in whom the IL-1 blockade …

… As with pathogenic Yersinia species, enteric bacterial pathogens have also been shown
to manipulate apoptotic signaling to successfully colonize the gut [35], [36]; however, direct …

… Caspase‐1 is activated by the formation of the multi‐protein complexes termed …
pathogen‐recognition receptor (eg NLRP3) and the adaptor protein ASC, which recruits caspase‐1. …

… Here, we show that caspase-8 and its adapter FADD act in IECs … Mice with IEC-specific FADD
or caspase-8 deficiency developed … ileitis caused by epithelial caspase-8 ablation, but only …

… For example, protection against most intracellular pathogens requires … immune responses
to a pathogen. Ag dose (6), APCs (7, … blockade of PI3′-K permitted the generation of active …