… initiator caspases that induce them [2]. Extrinsic apoptosis is induced by caspases 8 and
10, … stimulation, whereas intrinsic apoptosis is induced by caspase-9, which is activated by …

… In addition, caspase-8 was required for the release of active caspase-1 from T. gondii-…
Surprisingly, caspase-8 was dispensable for the synthesis and cleavage of IL-1β, but caspase-8 …

… Caspase-8 in endothelial cells results in small intestinal hemorrhages and bowel inflammation,
while all other organs remained unaffected. We also show that Caspase-8 … for pathogens …

… to pathogen-induced cytokine secretion in intestinal macrophages has not been reported.
We found that IL-18R blockade … Importantly, we identify that upon pathogenic infection of …

… a caspase-9 inhibitor (Z-LEHD-fmk) did not. Treatment of mast cells with caspase-3
inhibitor Z-DEVD-fmk or caspase-8 … by ETA, suggesting a role for caspase-8 and -3 in ETA-induced …

… These findings suggest that caspase-8 acts to restrain excessive activation of pathways of
response to intracellular pathogenic components and to DAMPs and that its failure to so in the …

… pathogens and is mediated by an array of pathogen-encoded virulence determinants.
Pathogen-… The antiapoptotic activity correlates with the blockade of mitochondrial cytochrome c …

… Here, we show that caspase-8 and its adapter FADD act in IECs … Mice with IEC-specific FADD
or caspase-8 deficiency developed … ileitis caused by epithelial caspase-8 ablation, but only …

… a variety of pathogenic or physiologic stimuli to initiate activation of inflammatory caspases,
… serves as a global sensor of pathogen-associated molecular patterns (PAMPs) and damage…

… Interestingly, caspase-8 also contributed to the release of IL-… functions of caspase-8
and define a novel role for caspase-8 in … Pathogen blockade of TAK1 triggers caspase8−dependent …