… as a selective target for the treatment of atherosclerosis: Role of mitochondrial DNA mutations and defective mitophagy in the pathogenesis of atherosclerosis and …

AN Orekhov, AV Poznyak, IA Sobenin… - Current …, 2020 - ingentaconnect.com
… may open new perspectives for atherosclerosis treatment. Conclusion: … targeting
antioxidant therapies appear to be promising for the development of treatment of atherosclerosis

Inflammation: a novel therapeutic target/direction in atherosclerosis

B Li, W Li, X Li, H Zhou - Current Pharmaceutical Design, 2017 - ingentaconnect.com
atherosclerosis successfully [6]. Although lipoproteins and lipid-related factors are very
important in the pathogenesis of atherosclerosis, … trials targeting inflammation in atherosclerosis

Atherosclerosis: current pathogenesis and therapeutic options

C Weber, H Noels - Nature medicine, 2011 - nature.com
… The atherosclerosis field is so vast that attempts to comprehensively cover all aspects will …
atherosclerosis and to discuss clinical applications of targeting inflammation in atherosclerosis

Novel mechanisms and therapeutic targets in atherosclerosis: inflammation and beyond

C Weber, AJR Habenicht… - European heart …, 2023 - academic.oup.com
… to be critical and powerful modulators of immune responses in atherosclerosis. We thought
that selective targeting of signalling molecules directly downstream of CD40 such as TNF-…

The pathogenesis of atherosclerosis: an overview

CJ Schwartz, AJ Valente, EA Sprague… - Clinical …, 1991 - Wiley Online Library
In this unifying hypothesis directed to the etiology and pathogenesis of atherosclerosis, the
importance of focal arterial lesion‐prone sites has been emphasized. Key initial participants …

[HTML][HTML] Targeted inhibition of STAT3 as a potential treatment strategy for atherosclerosis

Q Chen, J Lv, W Yang, B Xu, Z Wang, Z Yu, J Wu… - Theranostics, 2019 - ncbi.nlm.nih.gov
… and effective target sites for atherosclerosis. Therefore, the mechanism of atherosclerosis
has … may contribute to the application of STAT3 as a novel target of atherosclerosis therapies. …

CANTOS trial validates the inflammatory pathogenesis of atherosclerosis: setting the stage for a new chapter in therapeutic targeting

C Weber, P von Hundelshausen - Circulation Research, 2017 - Am Heart Assoc
… inflammatory hypothesis of atherosclerosis and cancer … pathogenesis of atherosclerotic
disease in conjunction with or beyond elevated lipid levels; however, ultimate proof by selective

Pathogenesis of atherosclerosis

E Falk - Journal of the American College of cardiology, 2006 - jacc.org
… The most devastating consequences of atherosclerosis, such … why atherosclerosis develops
but rather why atherosclerosis, … and thrombosis averted, atherosclerosis would be a much …

[HTML][HTML] Pathogenesis of atherosclerosis: A multifactorial process

RB Singh, SA Mengi, YJ Xu, AS Arneja… - Experimental & Clinical …, 2002 - ncbi.nlm.nih.gov
Targeted disruption of the MSR gene results in the reduction of atherosclerotic lesions in
apolipoprotein E-deficient animals. Macrophages from MSR-deficient mice exhibit a marked …

Inflammation and atherosclerosis: signaling pathways and therapeutic intervention

P Kong, ZY Cui, XF Huang, DD Zhang… - … and targeted therapy, 2022 - nature.com
… in atherosclerosis, and discuss the preclinical studies targeting these key pathways for
atherosclerosis, the clinical trials that are going to target some of … and atherosclerosis in the clinic. …