Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm

B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
… KLF4 contributes to aneurysm pathogenesis primarily through regulating SMC … aneurysm
formation, which provides support for the role of phenotypic switch in aneurysm pathogenesis (…

Current concepts in the pathogenesis of abdominal aortic aneurysm

G Ailawadi, JL Eliason, GR Upchurch - Journal of vascular surgery, 2003 - jvascsurg.org
… The mechanisms for initiating and propagating these proteolytic enzymes in the … research
on the underlying pathogenesis of aortic aneurysms have underscored the complexity of this …

Understanding the pathogenesis of abdominal aortic aneurysms

H Kuivaniemi, EJ Ryer, JR Elmore… - Expert review of …, 2015 - Taylor & Francis
… An aortic aneurysm is a dilatation in which the aortic diameter is ≥3.0 cm. If left untreated, the
aortic wall … Although the mechanism of autoimmunity is not precisely known, we and others …

Etiology and pathogenesis of aortic aneurysm

CW Kotze, IG Ahmed - … of aortic aneurysms and aneurysm …, 2011 - books.google.com
… Despite several similarities in etiology and pathogenic mechanisms, it appears that TAA
differs in many ways from AAA. Current areas of interest include proteolytic degradation of the …

Cellular mechanisms of aortic aneurysm formation

RA Quintana, WR Taylor - Circulation Research, 2019 - Am Heart Assoc
… the mechanisms responsible for the initiation of aneurysms, and although these studies
have provided extremely valuable insights into the potential pathogenesis of aortic aneurysms, …

Pathophysiology and pathogenesis of aortic aneurysms: current concepts

PB Dobrin - Surgical Clinics of North America, 1989 - Elsevier
From an engineering point of view, the development of an arterial aneurysm is a classic
case of material failure that may involve two factors: excessive applied load and inadequate …

Pathogenesis of abdominal aortic aneurysm: an update and look toward the future

JJ Grange, V Davis, BT Baxter - Cardiovascular surgery, 1997 - Elsevier
… matrix remodeling which occurs with abdominal aortic aneurysm. A family of matrix-… aortic
aneurysm. Given the progress of the past decade, we can expect the identification of aneurysm-…

Pathogenesis of abdominal aortic aneurysms—cellular and biochemical mechanisms

A Wills, MM Thompson, M Crowther, RD Sayers… - European Journal of …, 1996 - Elsevier
… for elective aneurysm repair on the basis of aortic diameter. 4 … of aneurysm pathophysiology,
it is possible that aneurysm … current theories of aneurysm pathogenesis, with emphasis …

Aortic aneurysms: current pathogenesis and therapeutic targets

MJ Cho, MR Lee, JG Park - Experimental & Molecular Medicine, 2023 - nature.com
… , there are unknown pathogenic mechanisms involved in cellular heterogeneity … pathogenic
mechanisms of aortic aneurysms, which may enhance our understanding of aortic aneurysms

Pathogenesis of thoracic and abdominal aortic aneurysms

DC GUO, CL Papke, R He… - Annals of the New York …, 2006 - Wiley Online Library
aorta in the thoracic cavity and abdominal aortic aneurysms (AAAs) involving the infrarenal
abdominal aorta. Both … This review focuses on the comparison of the pathologic mechanisms