Imaging the progression of Alzheimer pathology through the brain

AD Smith - Proceedings of the National Academy of …, 2002 - National Acad Sciences
Alzheimer's disease (AD). Atrophy of brain tissue was a common finding, but a critical review
in 1990 concluded that “at present there is little definite evidence for clear anatomic brain …

Classification and basic pathology of Alzheimer disease

C Duyckaerts, B Delatour, MC Potier - Acta neuropathologica, 2009 - Springer
… The progression of tau pathology is stepwise and stereotyped from the entorhinal cortex, …
Various clinico-pathological types of Alzheimer disease have been described, according to the …

The complexities of the pathology–pathogenesis relationship in Alzheimer disease

RJ Castellani, G Perry - Biochemical pharmacology, 2014 - Elsevier
… versus those that occur in the setting of Alzheimer's disease (AD). Since putative biomarkers
disease, is the pathological progression consistent with a linear amyloid-tau progression. …

Alzheimer disease pathology as a host response

RJ Castellani, H Lee, X Zhu, G Perry… - … of Neuropathology & …, 2008 - academic.oup.com
… in Alzheimer disease (AD). The presumptions inherent in most studies and in the dogma of
the amyloid cascade concept are that these hallmark lesions in AD brains contain molecules …

Association of plasma clusterin concentration with severity, pathology, and progression in Alzheimer disease

M Thambisetty, A Simmons… - Archives of general …, 2010 - jamanetwork.com
… for the identification of blood-based Alzheimer disease (AD) biomarkers associated with
both in vivo disease pathology as well as rate of disease progression. C, Association of plasma …

Alzheimer disease and cerebrovascular pathology: an update

KA Jellinger - Journal of neural transmission, 2002 - Springer
disease (AD) and cerebrovascular lesions that may magnify the effect of mild AD pathology
and promote progression of … Vascular pathology in the aging brain and in AD includes: 1. …

[HTML][HTML] Brain and blood metabolite signatures of pathology and progression in Alzheimer disease: A targeted metabolomics study

VR Varma, AM Oommen, S Varma, R Casanova… - PLoS …, 2018 - journals.plos.org
… AD pathology and disease progression (Endophenotype Association Score in Early Alzheimer’s
Disease [… severity of AD pathology at autopsy and AD progression across prodromal and …

Vascular burden and Alzheimer disease pathologic progression

RY Lo, WJ Jagust, M Weiner, P Aisen, M Weiner… - Neurology, 2012 - AAN Enterprises
… not affect AD-specific pathologic progression, suggesting that the … Alzheimer disease (AD)
and vascular pathology are common in the elderly population, and multiple brain pathologic

Progression of clinical deterioration and pathological changes in patients with Alzheimer disease evaluated at biopsy and autopsy

PL Di Patre, SL Read, JL Cummings… - Archives of …, 1999 - jamanetwork.com
… marker for diagnostic purposes and as a measurement of clinical progression of AD. Alzheimer
disease pathological markers develop in vulnerable brain regions in an uneven manner …

Regulatory T cells delay disease progression in Alzheimer-like pathology

C Dansokho, D Ait Ahmed, S Aid, C Toly-Ndour… - Brain, 2016 - academic.oup.com
… in both physiological and pathological settings. Here, we analysed the impact of regulatory
T cells on spontaneous disease progression in a murine model of Alzheimer’s disease. Early …