… the overlying cartilage in supporting joints, promoting further deterioration and cartilage
erosion. … cartilage breakdown and/or increasing subchondral bone turnover is gaining support. …

… Osteoarthritis (OA) is characterized by a degeneration of articular cartilage, in which the
breakdown … tissues (these being the cartilage and the synovial membrane) implicated in the …

… Excess of metalloproteases over tissue inhibitor of metalloprotease may contribute to
cartilage degradation in osteoarthrtis and rheumatoid arthritis. Lab Invest 1994; 70: 807-15. 37. …

… Interleukin-l is a multifunctional pro inflammatory cytokine that affects most cell types and
results in several effects including lymphokine production, cartilage breakdown, interfering with …

… including aggrecanases and MMPs that induce cartilage degradation, and the proinflammatory
cytokines (… Contribution of the NF-κB pathway to cartilage degradation and OA pathology …

… Moreover, the involvement of fibronectin in cartilage degradation is also apparent when
fragments of the protein induce the expression of inflammatory cytokines, chemokines, and …

… During the development of osteoarthritis, the normally quiescent chondrocytes become …
and degradation of cartilage matrix, the appearance of chondrocyte clusters, increased cartilage …

… cartilage degradation in the serum or urine of patients; however, there are very few that detect
the novel formation of cartilage. … -invasive biomarkers of cartilage formation can provide an …

… age-dependent deterioration of chondrocyte function that leads to cartilage dysfunction in …
in the arthritic joint, further contributing to the age-related degradation of articular cartilage, …

… cartilage degradation. Fibrillation, erosion and cracking initially appear in the superficial layer
of cartilage … cartilage matrix degradation to which an ineffectual attempt at repair is made. …