… of UDCA (tauroursodeoxycholic acid [TUDCA]) against glycochenodeoxycholic acid (GCDCA)-…
Hepatocytes were exposed to GCDCA, TUDCA, the glyco-conjugate of UDCA (GUDCA), …

… MK2206 or siRNA targeting of Akt abolished the beneficial effects of TUDCA. Taken together,
our results indicate that TUDCA may attenuate early brain injury via Akt pathway activation. …

… We aimed to study if TUDCA can decrease taurolitholic acid (TLCA)-… activity were unaffected
by TUDCA (75 μM). However, … by blocking proapoptotic pathways, but also by activation of …

… In conclusion, an integrin-, Erk 1/2- and p38 MAPK -dependent dual signaling pathway may
be relevant for the choleretic effect of TUDCA in normal liver, but played no major role in the …

… may regulate glucose homeostasis by interacting with the IR, which activates the PI3K/AKT
pathway. For this, we investigated, using in silico and in vivo experiments, whether the …

… of TUDCA on different intracellular pathways. Factors and pathways inhibited by TUDCA
are shown in red; pathways … membrane, TUDCA also activated the Akt survival pathway and …

… that the survival pathway activated by TUDCA involves Akt signaling, including downstream
Bad phosphorylation and NF-κB activation. We conclude that TUDCA is neuroprotective in …

… Recently, a novel pathway via endoplasmic reticulum (ER) stress has been reported. We
assessed the role of tauroursodeoxycholic acid (TUDCA) in inhibition of caspase-12 activation …

… acids are steroid acids found predominantly in the bile of mammals. The bile acid conjugate
tauroursodeoxycholic acid (TUDCA) … of the proinflammatory pathway and probably reduced …

… Tauroursodeoxycholic acid (TUDCA) is a taurine conjugate of ursodeoxycholic … remains
unknown and the exact molecular pathways activated after TUDCA treatment in humans are still …