… In last years several improvements have been made in the management of prostate cancer
(… directed against AR pathway. Once PCa spreads outside the prostate, androgen deprivation …

… represent 1 pathway for the development of prostate cancer. … of prostate cancer cases is
consistent with this notion, although a causal relationship between infection and prostate cancer …

… 50% of prostate cancers harbor … prostate cancer development. During disease progression,
genomic and epigenomic abnormalities accrued and converged on prostate cancer pathways…

… or less) are diagnosed with metastatic prostate cancer at disease presentation. However, …
challenge of treating prostate cancer today. Our understanding of prostate cancer biology and …

… prostate cancer. This review summarizes the current understanding of the … pathways
involved in localized and metastatic prostate cancer, with an emphasis on the clinical implications …

… Prostate cancer (PCa) is the fifth leading cause of cancer death worldwide, and its incidence
has been increasing in the US since 1950, apparently related to an overall increase in life …

… remains a major cause of death in the US Pharmaceutical research has emphasised AR
modulation, and 9 agents approved by the FDA for prostate cancer target the AR pathway. …

… , and is critical for cancer cell proliferation, migration, … pathway, alterations in pathway
components commonly seen in advanced prostate cancer, and results of clinical trials of pathway …

… progression of prostate cancer in relation to the familial correlation of the disease, the genetic
… resulting in prostate cancer and the new molecular biology data regarding prostate cancer. …

… signaling in prostate and prostate cancer cells and to highlight the implications of the
complex interaction between these two unique signaling pathways for prostate cancer biology. …