… ) evidence and clinical implications with the use … clinical outcomes observed in clinical trials
[Citation12,Citation13]. We here discuss the available PD evidence and clinical implications …

… the hedgehog pathway, which have significant clinical implications in … pathways in
carcinogenesis, potential antagonists for hedgehog signaling inhibition and their clinical implications …

… inhibitors for this pathway are even more exciting. In this review, we summarize major advances
in the understanding of Hh signaling pathway … signaling and their clinical implications. …

… pathways. In this review, focusing on descending inhibitory pain pathways among pain
modulation pathways, we summarize the role of the descending inhibitory pain pathways and …

… Hh pathway signal transduction, discuss the models of pathway activation, review the clinical
data using Hh inhibitors, and discuss challenges to the development of pathway inhibitors. …

… COX activation, in turn, modulates l-arginine-NO pathway, and it has been shown that
COX inhibition decreases NOS activity in human platelets (13). Both COX and NOS …

… rapamycin) signaling pathway is commonly … pathway, alterations in pathway components
commonly seen in advanced prostate cancer, and results of clinical trials of pathway inhibitors …

… recently have engineered a polymeric nanoparticle encapsulating a small molecule
inhibitor, HPI-1 (Hh pathway inhibitor), which was shown to bypass the secondary mutational …

… pathway has become a challenging and, in the meantime, fascinating topic, when a large
number of experimental and clinical studies suggested that inhibition … , clinical implications and …

… is continued signaling through downstream pathways, despite the continued presence of
the inhibitor. Here, we focus on clinically relevant mechanisms of acquired resistance. …