… RAS mutant models but only additive in BRAF mutant models where the RAF complex is
dissociated from RAS … We discovered that pathway reactivation in RAS mutant models occurs at …

… Taken together, we speculate that the pathway reactivation in KRAS-mutant cell lines may
… mutant-specific RAS antibodies, we performed the RAS activation assays with homozygous …

… mutant tumors and, over time, results in pathway reactivation … Multiple studies have shown
that this pathway reactivation is … robust efficacy in KRAS mutant tumors (Hatzivassiliou et al. …

… with a combination of a MEK inhibitor (AZD6244 or trametinib) and the ERK inhibitor VTX-11e
overcame pathway reactivation and was more effective than either agent alone in NRAS-…

The three RAS genes comprise the most frequently mutated oncogene family in cancer. With
… of mutant RAS is required for tumor maintenance, it is widely accepted that effective anti-…

… We found that EGFR-mediated MAPK pathway reactivation leads to … BRAF-mutant colorectal
cancer cells, we investigated whether activation of RAS could account for the reactivation of …

… like those of BRAF inhibitors, where pathway reactivation occurs through the up-regulation …
, and binimetinib, can aid in preventing pathway reactivation that leads to the activation of …

… -mutant … reactivation of ERK-dependent signaling to bypass KRAS G12C blockade (4). Prior
work by our group and others has identified adaptive RAS pathway feedback reactivation as …

… deregulation of the Ras pathway in liver cancer. Ras and Raf gene mutations are rare events
… Hep3B cells with a DNA methylation inhibitor reactivates RASSF1A gene transcription 61. …

… in RAS mutant tumors To investigate the consequences of BRAF inhibition in RAS mutant
tumors… Our data have clear clinical implications because reactivation of the RAF-ERK pathway …